aims: arsenic contamination of natural water resources has become an important environmental problem in the world. the adsorption method by iron filings adsorbent or zero-valent iron was used. the study aimed to evaluate the efficiency of iron filings in arsenite removal from polluted water and to investigate the effect of magnetic field on the process. materials & methods: this interventional ...

Although epidemiologic evidence shows an association between inorganic arsenic in drinking water and increased risk of skin, lung, and bladder cancers, no animal model for arsenic carcinogenesis has been successful. This lack has hindered mechanistic studies of arsenic carcinogenesis. Previously, we and others found that low concentrations (< or =5 microm) of arsenite (the likely environmental ...

Arsenic is well established as a human carcinogen, but the molecular mechanisms leading to arsenic-induced carcinogenesis are complex and elusive. It is also not known if lncRNAs are involved in arsenic-induced liver carcinogenesis. We have found that MALAT1, a non-coding RNA, is over-expressed in the sera of people exposed to arsenite and in hepatocellular carcinomas (HCCs), and MALAT1 has a c...

BACKGROUND Arsenic has been considered as a carcinogen. Recently the issue of arsenic in drinking water raised an unprecedented social concern on human health, and yet the molecular mechanisms through which arsenic induces cancer remain unknown. Activation of cell survival pathway leading to the activation of eNOS has been associated with various types of cancer. The objective of this study was...

Thymus atrophy is induced by a variety of chemicals, including environmental contaminants and is used as a sensitive index to detect their adverse effects on lymphocytes. In the present study we adopted a toxicogenomics approach to identify the pathways that mediate the atrophy induced by arsenite. We also analyzed gene expression changes observed in the course of thymus atrophy by 2,3,7,8-tetr...

Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer death in the United States. Cisplatin is a DNA damaging agent initially effective against EOC but limited by resistance. P53 plays a critical role in cellular response to DNA damage and has been implicated in EOC response to platinum chemotherapy. In this study, we examined the role of p53 status in EOC response to a n...

Nuntharatanapong, Nopparat, Kai Chen, Palarp Sinhaseni, and John F. Keaney, Jr. EGF receptor-dependent JNK activation is involved in arsenite-induced p21 upregulation and endothelial apoptosis. Am J Physiol Heart Circ Physiol 289: H99–H107, 2005. First published February 25, 2005; doi:10.1152/ajpheart.00901.2004.—Arsenic exposure is associated with an increased risk of atherosclerosis and vascu...

Sodium arsenite (NaAsO2), at 10% of its median lethal dose, was administered to rats with and without vitamin C pretreatment. Liver microsomal fraction was isolated and the activity of Ca2+-ATPase was assayed. Sodium arsenite was found to inhibit the activity of the liver microsomal Ca2+-ATPase to 50% to that of control rats. The specific activity of the enzyme in rats administered sodium arsen...

The functionalization of polysaccharides with synthetic nanopolymers has attracted great attention owing to the applications this method in many industrial fields. This work aimed investigate effect arsenic trioxide on dextran. Dextran-arsenite nanoparticle formation was induced by microwave sulfuric acid as a catalyst. Various analytical techniques were used verify structure nanopolymers. Besi...

Transcriptional analyses are discussed to provide a deeper understanding of the molecular mechanisms underlying toxic effects. Thus, they can complement classic ecotoxicological test methods and potentially allow the identification of biomarkers associated to the exposure of chemical stressors and or adverse biological effects. This feasibility study intended to identify a set of potential gene...