نتایج جستجو برای: aromatase inhibitory

تعداد نتایج: 132961  

Journal: :The Journal of steroid biochemistry and molecular biology 2011
Bin Su Cynthie Wong Yanyan Hong Shiuan Chen

It has been demonstrated that growth factors produced by breast cancer cells stimulate aromatase expression in both breast cancer and adjacent adipose fibroblasts and stromal cells. However, whether these growth factors affect aromatase activity by other mechanisms still remain unclear. In the current study, MCF-7aro and T47Daro aromatase transfected breast carcinoma cells were used to explore ...

Journal: :Endocrine-related cancer 1999
R R Tekmal N Kirma K Gill K Fowler

To test directly the role of breast-tissue estrogen in initiation of breast cancer, we have developed the aromatase-transgenic mouse model and demonstrated for the first time that increased mammary estrogens resulting from the overexpression of aromatase in mammary glands lead to the induction of various preneoplastic and neoplastic changes that are similar to early breast cancer. Continued ove...

Journal: :acta medica iranica 0
f. akbary-asbagh z. heidar f. frozan-fard k. nouri o. azmodeh a. ghasemynejad

combination therapy with clomiphene citrate plus gonadotropin (clomiphene citrate plus hmg) in induction ovulation reduce the gonadotropins dose but antiestrogenic effect of c.c. can decrease pregnancy rate. in a randomized clinical trial we compared 3 treatment protocol for induction ovulation and intra uterine insemination (i/o plus iui) in women with infertility history more than one year, n...

Journal: :Frontiers in bioscience : a journal and virtual library 1998
S Chen

Estrogens play an important role in breast cancer development. Aromatase (CYP19), a cytochrome P450, is the enzyme that synthesizes estrogens. Aromatase is expressed at a higher level in human breast cancer tissue than in normal breast tissue using enzyme activity measurement, immunocytochemistry, and RT-PCR analysis. Cell culture, animal experiments using aromatase-transfected breast cancer ce...

Journal: :Cancer research 2006
Kotha Subbaramaiah Louise R Howe Elisa R Port Edi Brogi Jack Fishman Catherine H Liu Timothy Hla Clifford Hudis Andrew J Dannenberg

Cytochrome P450 aromatase (aromatase), a product of the CYP19 gene, catalyzes the synthesis of estrogens from androgens. Given the significance of estrogen synthesis in hormone-dependent breast carcinogenesis, it is important to elucidate the mechanisms that regulate CYP19 expression. The main objective of this study was to define the interrelationship between HER-2/neu, cyclooxygenase-2 (COX-2...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
P E Johnson A Buzdar

Aromatase inhibitors are endocrine agents with a different mode of action than tamoxifen against breast tumors. In postmenopausal women, estrogen concentrations are maintained primarily via aromatase, a cytochrome P-450 enzyme that acts at the final step in the estrogen synthesis pathway. The first clinically available aromatase inhibitor, aminoglutethimide, was introduced for the second-line t...

2014
Nino Tabatadze Satoru M. Sato Catherine S. Woolley

In vitro studies show that estrogens acutely modulate synaptic function in both sexes. These acute effects may be mediated in vivo by estrogens synthesized within the brain, which could fluctuate more rapidly than circulating estrogens. For this to be the case, brain regions that respond acutely to estrogens should be capable of synthesizing them. To investigate this question, we used quantitat...

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