Time-optimal nonlinear control of rest to rest maneuvers of double arms robot is solved using Pontryagin's Minimum Principle. A numerical non-optimal solution satisfying the state equations with the initial and the nal boundary conditions is found and used to obtain a good approximation of the initial values of the costates. Then the corresponding nonlinear two-point boundary-value problem is s...

A sensitive and convenient method for detecting epidermal growth factor receptor (EGFR) T790M mutations from circulating tumor DNA (ctDNA) in advanced non-small cell lung cancer (NSCLC) patients with acquired EGFR-TKI resistance would be desirable to direct patient sequential treatment strategy. A comparison of two platforms for detecting EGFR mutations in plasma ctDNA was undertaken. Plasma sa...

background and objectives: jak2 is a nonreceptor tyrosine kinase that plays a major role in myeloid disorders. jak2v617f mutation is characterized by a g to t transverse at nucleotide 1849 in exon 12 of the jak2 gene, located on the chromosome 9p, leading to a substitution of valine to phenylalanine at amino acid position 617 in the jak2 protein. in this study we compared two molecular methods ...

background myeloproliferative disorders are a group of diseases characterized by increased proliferation of myeloid lineage. in addition to jak2v617f mutation, several mutations in the c-mpl gene were described in patients with philadelphia-negative chronic myeloproliferative disorders that could be important in the pathogenesis of diseases. the aim of present study was to investigate the frequ...

this article studies harmful effects of various forms of illegal trade and illegitimate use of small arms and light weapons on the human life. the authors continue to present a definition of small arms and light weapons and then scrutinize the different types of their illicit trade and various aspects of their impact on armed conflicts, living conditions of women and children, refugees, humanit...