The uterine tissue consists of unstriped muscle fibre and ganglia of the sympathetic system imbedded in it. The sacral roots and pelvic nerve do not enter into the composition of the uterine plexus. In the rabbit, irritation of the hypogastric nerve produces vasoconstriction and contraction of the uterus. In cats, stimulation of the hypogastric nerve produces at one time contraction and at othe...

In mammals, sperm migrate through the female reproductive tract to reach the egg; however, our understanding of this journey is highly limited. To shed light on this process, we focused on defining the functions of seminal vesicle secretion 2 (SVS2). SVS2(-/-) male mice produced sperm but were severely subfertile, and formation of a copulatory plug to cover the female genital opening did not oc...

A few investigators1)-7) have reported that abnormal sensitivity of the uterus to ovarian hormones exists among the endocrine disorders which are regarded as due to endocrinological disturbances. However, generally test measuring of hormones has been undertaken and the dosages of hormone preparations have been applied in diagnosing and treating endocrine disorders, and the problem on the sensit...

Background: Methotrexate (MTX) is used as an antineoplastic drug in the treatment of various cancers and non-cancerous diseases. Ovarian ablation is considered to be effective in delaying recurrence of cancer and increasing survival in young women. When added to chemotherapy, it is less clear that this technique is effective. Uniqueness of the present study is that we used ovariectomized (OVX) ...

BACKGROUND Uterine transplantation could serve as a tool in studies of the physiology of implantation/pregnancy, and is also a possible future treatment for patients with absolute uterine infertility. Here, the first live-born offspring in any uterine transplantation model is reported. METHODS A syngeneic mouse model with a uterus transplanted, by end-to-side aorta/vena cava vascular anastomo...

Background: Methotrexate (MTX) is used as an antineoplastic drug in the treatment of various cancers and non-cancerous diseases. Ovarian ablation is considered to be effective in delaying recurrence of cancer and increasing survival in young women. When added to chemotherapy, it is less clear that this technique is effective. Uniqueness of the present study is that we used ovariectomized (OVX) ...

Uterus transplantation has been considered as an alternative management modality in the last few years for adoption or gestational surrogacy for women with absence of uterus due to congenital or acquired reasons. Surrogacy is legal in only a few countries because of ethical, social and legal issues. Up to date, a total of 11 uterus transplantation cases have been reported in which uteri were ha...

BACKGROUND Most of the reports on mothers with bicornuate uterus analyze fertility, reproductive capacity, and pregnancy outcomes. Very few of them, however, mention the risk for congenital anomalies in their offspring. Further, to our knowledge, no epidemiologic studies estimating the risk for congenital defects and analyzing the type of anomalies observed in infants born to mothers with bicor...

inflammatory myofibroblastic tumor (imt) is an aggressive benign mass that may arise from various tissues and organs with a great variability of histological and clinical appearances. due to variable and nonspecific imaging findings, diagnosis of imt is not obtained before surgery. the aim of this paper is to present ct and mri findings during four-year follow-up of complete, spontaneous regres...

background: various uterine disorders lead to infertility in women of reproductive ages. this study was performed to describe common uterine causes of infertility and sonographic evaluation of them for midwives.   methods:to study the literatures, manuscripts published at “pubmed”, “elsevier”, “google scholar”, “sid” and original text books, between 1985 and 2015, were carefully reviewed, using...