1. Barberá JA, Escribano P, Morales P, Gómez MA, Oribe M, Martínez A, et al. Estándares asistenciales en hipertensión pulmonar. Rev Esp Cardiol. 2008;61:170-84. 2. Angell M. Is academic medicine for sale? N Engl J Med. 2000;342:1516-8. 3. Bodenheimer T. Uneasy alliance —clinical investigators and the pharmaceutical industry. N Engl J Med. 2000;342:1539-44. 4. Campbell EG, Weissman JS, Vogeli C,...

In an open network environment, the remote authentication scheme using smart cards is a very practical solution to validate the legitimacy of a remote user. In 2003, Wu and Chieu presented a user-friendly remote authentication scheme using smart cards. Recently, Wang, Li, and Tie found that Wu–Chieu s scheme is vulnerable to the forged login attack, and then presented an improvement to eliminat...

The microtubule cytoskeleton is crucial for the internal organization of eukaryotic cells. Several microtubule-associated proteins link microtubules to subcellular structures. A subclass of these proteins, the plus end-binding proteins (+TIPs), selectively binds to the growing plus ends of microtubules. Here, we reconstitute a vertebrate plus end tracking system composed of the most prominent +...

This paper addresses the problem of locally verifying global properties. Several natural questions are studied, such as “how expensive is local verification?” and more specifically “how expensive is local verification compared to computation?” A suitable model is introduced in which these questions are studied in terms of the number of bits a node needs to communicate. In addition, approaches a...

Amos, D. B., Nicks, P. J., Peacocke, N., and Sieker, H. 0. (1965). 7. clin. Invest., 44, 219. Bach, F., and Hirschhorn, K. (1964). Science, 143, 813. Bain, B., Vas, M. R., and Lowenstein, L. (1964). Blood, 23, 108. Bateman, A. J. (1965). Lancet, 1, 1117. Berroche, L., Maupin, B., Hervier, P., and Dausett, J. (1955). Vox Sang. (Basel), 5, 82. Brent, L., and Medawar, P. B. (1963). Brit. med. 7., ...

I Fischer, G. A., Ann. N. Y. Acad. Sci., 76, 673 (1957). 4Moorhead, P. S., unpublished results. 5 Billingham, R. E., in Transplantation of Tissues and Cells, ed. R. E. Billingham and W. S. Silvers (Philadelphia: Wistar Press, 1961). 6 Litchfield, J. T., Jr., J. Pharmacol. Exp. Therap., 97, 399 (1949). 7Stimpfling, J. H., Transpl. Bull., 27, 109 (1961). 8 Gurd, R. N., in Lipide Chemistry, ed. I)...

Antisense morpholino oligonucleotides (AMOs) can reprogram pre-mRNA splicing by complementary binding to a target site and regulating splice site selection, thereby offering a potential therapeutic tool for genetic disorders. However, the application of this technology into a clinical scenario has been limited by the low correction efficiency in vivo and inability of AMOs to efficiently cross t...