نتایج جستجو برای: ar

تعداد نتایج: 61795  

هدف: ایران و عربستان دو بازیگر مطرح خاورمیانه و رقیب منطقه‌ای یکدیگر محسوب می‌شوند. در این رابطه، عراق یکی از بازتاب‌های مهم سیاست‌های رقابتی ایران و عربستان در منطقه محسوب می‌شود. تحولات سیاسی و امنیتی سال 2003 میلادی در عراق، منجر به افزایش نقش و تأثیرگذاری جمهوری اسلامی ایران در صحنه سیاسی این کشور شد. در این راستا، عربستان در تلا...

پژوهش حاضر با هدف بررسی اثر رهبری تحول‌گرا بر تعالی سازمانی دانشگاه پیام نور با نقش واسطه‌ای توانمندسازی ساختاری و روان‌شناختی کارکنان، به روش توصیفی- همبستگی در یک نمونه 362 نفری از کارکناندانشگاه‌های پیام نور استان همدان انجام شد. جهت جمع‌آوری داده‌ها از 4 پرسشنامه روا و معتبر و برای تحلیلداده‌های گردآوری‌شده، از آزمون‌های...

2016
Binod Kumar Salar Khaleghzadegan Brian Mears Koji Hatano Tarana A. Kudrolli Wasim H. Chowdhury David B. Yeater Charles M. Ewing Jun Luo William B. Isaacs Luigi Marchionni Shawn E. Lupold

The Androgen Receptor (AR) plays a key role in prostate biology and in the progression of prostate cancer (PCa) to castration resistance. The role of microRNAs (miRNAs) in aberrant AR signaling have not been fully characterized. Here we screened a library of 810 miRNA mimics to identify miRNAs that alter AR activity in complementary functional assays including protein lysate microarray (LMA) qu...

Journal: :Circulation journal : official journal of the Japanese Circulation Society 2003
Hideshi Tomita Osamu Yamada Ken-Ichi Kurosaki Toshikatsu Yagihara Shigeyuki Echigo

To analyze the clinical significance of eccentric aortic regurgitation (AR) complicating the right coronary cusp prolapse associated with a ventricular septal defect (VSD), the Doppler echocardiograms of 129 patients were reviewed. In 102 patients, AR was classified as mild and in 27 patients it was classified as moderate. Eccentric AR was defined as the jet distributing in an eccentric directi...

Journal: :Asian journal of andrology 2012
Qiao-Xia Zhang Xiao-Yan Zhang Zhen-Ming Zhang Wei Lu Ling Liu Gang Li Zhi-Ming Cai Yao-Ting Gui Chawnshang Chang

Androgen and androgen receptor (AR) play important roles in male spermatogenesis and fertility, yet detailed androgen/AR signals in Sertoli cells remain unclear. To identify AR target genes in Sertoli cells, we analyzed the gene expression profiles of testis between mice lacking AR in Sertoli cells (S-AR(-/y)) and their littermate wild-type (WT) mice. Digital gene expression analysis identified...

Journal: :Endocrinology 2007
K A Walters C M Allan M Jimenez P R Lim R A Davey J D Zajac P Illingworth D J Handelsman

The role of classical genomic androgen receptor (AR) mediated actions in female reproductive physiology remains unclear. Female mice homozygous for an in-frame deletion of exon 3 of the Ar (AR(-/-)) were subfertile, exhibiting delayed production of their first litter (AR(+/+) = 22 d vs. AR(-/-) = 61 d, P < 0.05) and producing 60% fewer pups/litter (AR(+/+): 8.1 +/- 0.4 vs. AR(-/-): 3.2 +/- 0.9,...

Journal: :EMBO Reports 2007
Charles E Massie Boris Adryan Nuno L Barbosa-Morais Andy G Lynch Maxine G Tran David E Neal Ian G Mills

The androgen receptor (AR) initiates important developmental and oncogenic transcriptional pathways. The AR is known to bind as a homodimer to 15-base pair bipartite palindromic androgen-response elements; however, few direct AR gene targets are known. To identify AR promoter targets, we used chromatin immunoprecipitation with on-chip detection of genomic fragments. We identified 1,532 potentia...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Meng-Yin Tsai Shauh-Der Yeh Ruey-Sheng Wang Shuyuan Yeh Caixia Zhang Hung-Yun Lin Chii-Ruey Tzeng Chawnshang Chang

Using a Cre-Lox conditional knockout strategy, we generated a germ cell-specific androgen receptor (AR) knockout mouse (G-AR(-/y)) with normal spermatogenesis. Sperm count and motility in epididymis from AR(-/y) mice are similar to that of WT (G-AR(+/y)) mice. Furthermore, fertility tests show there was no difference in fertility, and almost 100% of female pups sired by G-AR(-/y) males younger ...

2017
Kazuaki Kita Masayuki Shiota Masako Tanaka Asuka Otsuka Masaki Matsumoto Minoru Kato Satoshi Tamada Hiroshi Iwao Katsuyuki Miura Tatsuya Nakatani Shuhei Tomita

Androgen deprivation therapy is initially effective for treating patients with advanced prostate cancer; however, the prostate cancer gradually becomes resistant to androgen deprivation therapy, which is termed castration-resistant prostate cancer (CRPC). Androgen receptor splice variant 7 (AR-V7), one of the causes of CRPC, is correlated with resistance to a new-generation AR antagonist (enzal...

2016
Jordy J. Hsiao Melinda M. Smits Brandon H. Ng Jinhee Lee Michael E. Wright

Aberrant androgen receptor (AR)-dependent transcription is a hallmark of human prostate cancers. At the molecular level, ligand-mediated AR activation is coordinated through spatial and temporal protein-protein interactions involving AR-interacting proteins, which we designate the "AR-interactome." Despite many years of research, the ligand-sensitive protein complexes involved in ligand-mediate...

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