In two clinical situations associated with hyperfibrinolysis the administration of antifibrinolytic drugs resulted in clinical haemostasis. The dilute clot lysis time and fibrin plate activity test but not the euglobulin lysis time reflected this control of excessive fibrinolysis by the antifibrinolytic drugs. The inhibition by epsilon-amino-caproic acid (EACA) of hyperfibrinolysis induced in v...

BACKGROUND Epidural anaesthesia and analgesia are indicated for oesophageal surgery. A rare but serious complication is spinal haematoma, which can occur on insertion, manipulation or withdrawal of catheters. Evidence and guidelines are vague regarding which tests are appropriate and how to interpret their results. We aimed to describe how routine coagulation test results change during oesophag...

BACKGROUND Traumatic hemothorax (HTX) has been demonstrated to predictably contain low fibrinogen, low hematocrit, and low platelet counts. When analyzed on its own, shed HTX demonstrates coagulopathy. However, when mixed with normal pooled plasma (NPP) at physiologically relevant dilutions, HTX demonstrates accelerated coagulation. We hypothesize that when HTX is mixed with a patient's own pla...

Chelidonium majus is a well-known source of biologically active compounds. Most them are alkaloids, which used in researches and for tradition medicine. In this study, we explored the influence C. crude total extract onto blood coagulation system vitro, primary secondary hemostasis. Aim. To study process. Methods. Turbidimetry plasma, APTT test with chromogenic substrates, platelet aggregation ...

INTRODUCTION Prothrombin time (PT) and activated partial thromboplastin time (APTT) sensitivity for detecting isolated factor deficiencies varies with different reagents and coagulometers. The Clinical and Laboratory Standards Institute (CLSI) H47A2 guideline proposed a method to calculate these sensitivities, but some inconsistency has been reported. This study aimed to calculate factor sensit...

Hematol Transfus Int J 2017, 4(2): 00078 those using the anti-coagulant agent, warfarin [4,5]. One case of a patient undergoing coronary artery bypass grafting was noted among 7cases of surgery-associated acquired hemophilia [2]. A 66-year-old man underwent aortic valve replacement for severe aortic valve stenosis. After surgery, he was administered warfarin (2mg/day) for anticoagulation and th...

OBJECTIVE To determine the coagulation abnormalities and relationship between abnormal clotting tests and the risk of gastrointestinal bleeding (GI) among chronic liver disease (CLD) patients admitted at a tertiary care hospital in Pakistan. METHODS Adult CLD patients admitted at Liaquat University Hospital Jamshoro, during Nov 2004-Oct 2005, were included in the study. The patients blood wer...

BACKGROUND High levels of blood lipids have been associated with high levels of coagulation factors. We investigated whether blood lipids influence the results of global coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin generation assay (TGA). METHODS PT, aPTT, and TGA, along with procoagulant and anticoagulant factors, were measure...

Introduction. Dabigatran is an oral direct thrombin inhibitor which has been approved for prophylaxis of stroke in patients with atrial fibrillation. The use of dabigatran etexilate increased rapidly due to many benefits. However, questions have been raised constantly regarding the safety of dabigatran etexilate. Case. A 58-year-old Caucasian male with a history of recurrent paroxysmal atrial f...