INTRODUCTION Alcohol use by persons living with HIV/AIDS (PLWHA) negatively impacts the public health benefits of antiretroviral therapy (ART). Using a standardized alcohol assessment tool, we estimate the prevalence of alcohol use, identify associated factors, and test the association of alcohol misuse with sexual risk behaviors among PLWHA in Uganda. METHODS A cross-section of PLWHA in Kamp...

BACKGROUND Arthroscopic patellar release (APR) is utilized for minimally invasive surgical treatment of patellar tendinopathy. Evidence regarding long-term success following the procedure is limited. Also, the influence of age and preoperative performance level, are incompletely understood. The aim of this study was to investigate whether APR translates into sustained pain relief over a long-te...

BACKGROUND Mutation in the tumor suppressor gene TP53 is an early event in the development of high-grade serous (HGS) ovarian cancer and is identified in more than 96 % of HGS cancer patients. APR-246 (PRIMA-1(MET)) is the first clinical-stage compound that reactivates mutant p53 protein by refolding it to wild type conformation, thus inducing apoptosis. APR-246 has been tested as monotherapy i...

Editor's note: Increasingly, quality improvement initiatives emphasize public reporting of hospital performance measures, to encourage providers to improve, to help consumers pick providers, and to determine provider payments. Although these measures are based on compliance with well-established processes of care, it is unknown whether quality measured in this way is correlated with, or predict...

Most people sooner or later experience dilemmas or uncertainties involving questions of meaning, purpose, value, and fulfillment. Such questions emerge in the context of relationships, career, momentous change, personal responsibility, aspiration or disappointment, and decision-making under risk or potential conflict of interest. Normal problems of living are not regarded as “diseases”; rather,...

The acute phase response (APR) is accompanied by major changes in micronutrient status. It is important to be able to quantitate the degree of APR, which can then be related to the accompanying alterations in micronutrient levels. A rapid and convenient means of achieving this, viz. the use of an animal model in which APR can be induced, would facilitate such an investigation. The aim of the pr...

OBJECTIVES The aminoglycoside apramycin has been used extensively in animal husbandry in the UK since 1978. This study aimed to determine both whether calves that had never been treated with aminoglycoside antibiotics harboured apramycin-resistant (apr(R)) commensal Escherichia coli, and the mode of spread of the resistance gene. METHODS Apr(R) E. coli from weekly calf faecal samples were typ...

BACKGROUND After total mesorectal excision for rectal cancer, many surgeons try to avoid an abdominoperineal resection (APR) by performing a transanally double stapled low colo-rectal anastomosis (LRA), frequently without a pouch. This policy is mainly based on the assumption that the quality of life after such LRA is higher than after APR. It has been suggested that a better functional outcome...

Automated program repair (APR) tools apply fault localization (FL) techniques to identify the locations of likely faults to be repaired. The effectiveness and performance of APR depends in part on the FL method used. If FL does not identify the location of a fault, the application of an APR tool will not be effective — it will fail to repair the fault. If FL assigns a faulty location a low prio...

Many spatio-temporal access methods, such as the HR-tree, the 3DR-tree, and the MV3R-tree, have been proposed for timestamp and interval queries. However, these access methods have the following problems: the poor performance of the 3DR-tree for timestamp queries, the huge size and the poor performance of the HR-tree for interval queries, and the large size and the high update cost of the MV3R-...