The ability of the transcription factor NF-kappaB to upregulate anti-apoptotic proteins has been linked to the chemoresistance of solid tumors to standard chemotherapy. In contrast, recent studies have proposed that, in response to doxorubicin, NF-kappaB can be pro-apoptotic through repression of anti-apoptotic target genes. However, there is little evidence analyzing the outcome of NF-kappaB i...

Manuscript submitted 74 AbSTRACT Purpose By expression profiling of 31 apoptosis related genes in acute myeloid leukemia (AML) during the course of the disease we determined whether relapse is caused by emergence of apoptosis resistant subpopulations at diagnosis. Experimental design Samples were obtained from patients diagnosed with AML; 40 at diagnosis, 35 during follow-up and 20 at relapse. ...

The New World screwworm fly, Cochliomyia hominivorax, and the Australian sheep blow fly, Lucilia cuprina, are major pests of livestock. The sterile insect technique was used to eradicate C. hominivorax from North and Central America. This involved area-wide releases of male and female flies that had been sterilized by radiation. Genetic systems have been developed for making 'male-only' strains...