Both the active pharmaceutical ingredient and the vehicle physicochemical characteristics are retained to be the main features responsible for favorable topical bioavailability. Emulsion systems based on natural-origin alkyl polyglucoside (APG) emulsifier (cetearyl glucoside & cetearyl alcohol) present promising vehicles in contemporary pharmaceutical compounding [1], but require further charac...

CONTEXT Previous studies have demonstrated improvement of venous hemodynamics after surgical treatment of primary varicose veins of the lower extremities using air plethysmography (APG). PURPOSE To correlate the venous hemodynamics obtained by APG with the CEAP classification after surgical treatment of primary varicose veins. METHODS We studied 63 limbs of 39 patients (35 women and 4 men) ...

A probabilistic approach was applied in an ecological risk assessment (ERA) to characterize risk and address uncertainty employing Monte Carlo simulations for assessing parameter and risk probabilistic distributions. This simulation tool (ERA) includes a Window's based interface, an interactive and modifiable database management system (DBMS) that addresses a food web at trophic levels, and a c...

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15N shielding tensors were determined for the central peptide groups in GGV, AGG, and APG by single-crystal NMR. We find that the angle between the downfield component (delta11) and the N-H or the N-C(delta) (pro) bonds is in the range of 20-23 degrees and in accord with previous solid-state NMR measurements. However, AGG, unlike APG or GGV, has a distorted peptide plane, and delta11 lies appro...

Thermal anemometry measurements were performed to evaluate the heat and momentum transport characteristics of wall turbulence over a slightly heated, smooth flat plate with a stepchange in wall temperature. Single-wire, X-probe and triple-wire sensors were employed to measure mean and fluctuating velocity and temperature as well as Reynolds stress and heat flux productions. “Equilibrium” bounda...

PURPOSE To assess venous hemodynamics and quality of life at lest five years after varicose vein stripping. METHODS We conducted a prospective study with 39 patients (63 limbs) with primary lower limbs varicose veins. Preoperatively, all patients were subjected to clinical evaluation, duplex ultrassound, air plethysmography (APG), and CIVIQ questionnaire of quality of life. By APG, venous fil...