• The effect of aortic stenosis on the coronary circulation warrants further investigation because the few previous studies led to conflicting conclusions based on small series of experiments. Moreover, aortic stenosis presents a unique situation for a study of the determinants of coronary blood flow. On the one hand, the location of the stenosis, between the left ventricle and the aortic origi...

Localized discrete abdominal aortic stenosis leading to bilateral lower limbs claudication is uncommon in Asians, especially among women. We report on the case of a 63-year-old woman with localized discrete abdominal aortic stenosis manifested as claudication in her bilateral lower extremities. A magnetic resonance angiography showed a short and asymmetric abdominal aortic stenosis at the third...

BACKGROUND Among the vascular involvements of Takayasu arteritis, a supra-valvular aortic stenosis has been reported very rarely. We report a case of surgically corrected, supra-valvular aortic stenosis caused by Takayasu arteritis. CASE PRESENTATION A 32-year-old female was diagnosed with supra-valvular aortic stenosis by transthoracic echocardiography for the evaluation of cardiac murmur wi...

IN contrast to the usual clinical course of congenital aortic valvular stenosis in older children, the infant with severe aortic stenosis often has early symptomnatology, a malignant clinical course with severe cardiac failure, and a grim prognosis. Congenital aortic valvular stenosis inl inifancy is generally considered to occur ill two formns: (1) an isolated lesion, similar to those eases ob...

BACKGROUND Hypercholesterolemia and old age are clinical risk factors for development of aortic valve stenosis, and hypercholesterolemia is a putative therapeutic target. We tested the hypothesis that calcification and aortic valve stenosis would develop in genetically hypercholesterolemic old mice. METHODS AND RESULTS Twenty-four low-density lipoprotein receptor-deficient apolipoprotein B-10...

BACKGROUND To account for differences in body size in patients with aortic stenosis, aortic valve area (AVA) is divided by body surface area (BSA) to calculate indexed AVA (AVAindex). Cut-off values for severe stenosis are <1.0 cm2 for AVA and <0.6 cm2/m2 for AVAindex. OBJECTIVE To investigate the influence of indexation on the prevalence of severe aortic stenosis and on the predictive accura...

The supravalvular aortic stenosis is a rare congenital heart defect being very uncommon in adults. We present a case of supravalvular aortic stenosis in adult associated with anomalies of the aortic arch vessels and aortic regurgitation, which was submitted to aortic valve replacement and arterioplasty of the ascending aorta with a good postoperative course.

INTRODUCTION The aortic valve replacement is a standard operating procedure in patients with severe aortic stenosis. Structure of patients undergoing surgery ranges from young population with isolated mitral valvular disease to the elderly population, which is in addition to the underlying disease additionally burdened with comorbidity. One of the most commonly present factors that further comp...

BACKGROUND The relationship between ideal cardiovascular health reflected in the cardiovascular health score (CVHS) and valvular heart disease is not known. The purpose of this study was to determine the association of CVHS attainment through midlife to late life with aortic stenosis prevalence and severity in late life. METHODS AND RESULTS The following 6 ideal cardiovascular health metrics ...