Interferon-alpha (IFN ) is a therapeutic agent which is used for infectious and malignant diseases. Side effects such as flu-like symptoms, hematologic abnormalities and thyroid disease have been reported associated with this therapy. Thyroid disease manifests as development of thyrotoxicosis and it may be secondary to destructive thyroiditis or Graves’ disease. Here we report a 61-year-old fem...

INTRODUCTION Rheumatoid arthritis (RA) is known to be associated with a higher prevalence of antithyroid antibodies and autoimmune thyroid disease, but there have been few studies regarding the correlations between the presence of these antibodies and RA activity. OBJECTIVES The aim of this study was to analyze the relationship between antithyroid antibody titers and selected parameters of RA...

BACKGROUND Even though the presence of antithyroglobulin antibodies (TgAbs) represents a significant problem in the follow-up of patients with differentiated thyroid cancer (DTC), the current guidelines on the management of DTC that have been published in recent years contain no text concerning the methods to be used for detecting such antibody-related interference in thyroglobulin (Tg) measure...

Hashimoto encephalopathy (HE) is believed to be an immune-mediated disorder associated with Hashimoto's thyroiditis. It was suggested that neuropsychiatric symptoms, the presence of antithyroid antibody, and good response to steroids were important for the diagnosis of HE. It has been reported that homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), which are monoamine metabolit...

Cretinism is a term frequently applied to forms of thyroid deficiency occurring in utero or early in extra-uterine existence. Experimental cretinism probably had its beginnitgs in the first recorded extirpation of the thyroid in young animals, which seems to have been performed by Raynard' in 1834. Two years later, Astley Cooper' published his observations on thyroid extirpation in pups. His an...

A 32-year-old female patient presented complaining of increased flushing, perspiration and heat intolerance of 3 months’ duration. Medical history included idiopathic thrombocytopenic purpura of 4 years’ duration, which had been treated by splenectomy after failed immunosuppression with prednisone and azathioprine and was currently in remission. On examination, she was found to be clinically eu...

In the present study we evaluated the effects of iodine intake on the prevalence of thyroid dysfunction, autoimmunity, and goiter in two regions with different iodine status after two years of iodization in Turkey. In total 1733 adolescent subjects were enrolled into the study (993 from an iodine-sufficient area--the Eastern Black Sea Region (group 1) and 740 from an iodine-deficient area--Midd...

Acquired Hypothyroidism in a Newborn Treated with Amiodarone in the First Week of Life amiodarone after a week of life. Fetal tachycardia was diagnosed at 24th week of gestation and the mother was treated with digoxin until cesarean section at 34th week. Junctional ectopic tachycardia was confirmed by an electrocardiogram at birth, and amiodarone infusion was administered to the infant from the...

A case of autoimmune thyroiditis after long term treatment with lithium is described in a 29 year old Japanese woman with manic depression. Positive serum antithyroglobulin and antimicrosomal antibodies, diffuse goitre, and microscopic chronic thyroiditis, as well as the clinical history of long term lithium treatment were suggestive of lithium associated autoimmune thyroiditis. Microscopically...