Fever is one of the most common clinical symptoms of many diseases. Qingkailing (QKL) injection is widely used in China as a clinical emergency medicine due to its good antipyretic effects. It is a herbal formula which is composed by eight kinds of traditional Chinese medicines (TCM). As a kind of typical multiple constituents and multiple actions of TCM, it is very difficult to elaborate the a...

Acetaminophen (APAP) is an effective antipyretic and one of the most commonly used analgesic drugs. Unlike antipyretic non-steroidal anti-inflammatory drugs, APAP elicits hypothermia in addition to its antipyretic effect. Here we have examined the mechanisms responsible for the hypothermic activity of APAP. Subcutaneous, but not intrathecal, administration of APAP elicited a dose dependent decr...

Pharmacokinetic/pharmacodynamic modeling was used to characterize the antipyretic and anti-inflammatory effects of naproxen in rats. An indirect response model was used to describe the antipyretic effects of naproxen after short intravenous infusions. The model assumes that basal temperature (T(a)) is maintained by the balance of fever mediators given by a constant (zero order) rate of synthesi...

Ohwi (Leguminosae), has been clinically used as an antipyretic and spasmolytic agent in traditional Chinese medicine. Many Chinese herbal formulas contain Pueraria root as their major ingredient; most well-known being “Kakkon-To” (in Japanese), which is indicated for fever and chills with stiffness or rigidity of the neck and upper back. The constituents of Pueraria root have been studied exten...

OBJECTIVE To evaluate temperature changes in febrile children that received a single oral dose of ibuprofen (10 mg/kg), the dose recommended for high fever, or dipyrone (15 mg/kg), the dose recommended by the manufacturer, at 2, 3, 4, 5, 6, 7 and 8 hours after administration. METHODS This open-label randomized (1:1) controlled clinical tried enrolled 80 febrile boys and girls aged 6 months to...

Paracetamol (acetaminophen) is one of the most popular over-the-counter analgesic and antipyretic drugs. Paracetamol is available in different dosage forms: tablet, capsules, drops, elixirs, suspensions and suppositories. Dosage forms of paracetamol and its combinations with other drugs have been listed in various pharmacopoeias. The combination of paracetamol with dipyrone is used as an antipy...

The reason of this study was to evaluate the action of oxidative stress (OS) induced with hydrogen peroxide (H2O2) on the analgesic, antipyretic and anti-inflammatory effects of aspirin in 7-14 day old chicks. H2O2 at 0.5 % v/v in drinking water induced OS in age 7-14 of the chicks when given freshly. The analgesic Median Effective Dose (ED50) and acute Median Lethal Dose (LD50) values of aspir...

BACKGROUND The antipyretic effectiveness of rectal versus oral acetaminophen is not well established. This study is designed to compare the antipyretic effectiveness of two rectal acetaminophen doses (15 mg/kg) and (35 mg/kg), to the standard oral dose of 15 mg/kg. METHODS This is a randomized, double-dummy, double-blind study of 51 febrile children, receiving one of three regimens of a singl...

In the present study, methanol extracts of Costus speciosus Koen. aerial parts were assessed for antiinflammatory, analgesic and antipyretic activities in experimental animals. The antiinflammatory activity of methanol extract of Costus speciosus (400 and 800 mg/kg, p.o.) was evaluated using carrageenan-induced paw oedema test. Analgesic effect was evaluated using acetic acid-induced writhing a...