Temperature-sensitive transient receptor potential (TRP) channels such as TRPA1 and TRPV1 have been identified as downstream ion channel targets in the transduction of itch. As a member of the temperature-sensitive TRP family, the Ca2+-permeable nonselective cation channel TRPV3 is expressed abundantly in skin keratinocytes. Recent identification of gain-of-function mutations of human TRPV3 fro...

Impatiens balsamina is an annual herb, belongs to the family Balsaminaceae, commonly seen in India, China, and Korea. It erect plant known as rose balsam garden balsam. Studies shows that contain many valuable phytoconstituents such flavonoids, saponins, phenolics, naphthoquinones, glycosides. The used traditional medicine for their antimicrobial, anti-inflammatory, anti-allergic antidermatitic...

The case of a 42-year-old female patient with pronounced itching and exanthema, mainly in the area trunk lower limbs, is presented. Previously, took antihistamines without effect, was treated for scabies, but remained led to rash excoriations. From anamnesis, it found that has high level stress. According Hospital Anxiety Depression Scale, anxiety reached 14 points, depression 1 point. Function...

BACKGROUND Pruritus is a common and sometimes distressing symptom in many dermatological conditions. Response to conventional pharmaceutical agents may not be satisfactory, and adverse effects are real problems. OBJECTIVE To evaluate the short-term efficacy and adverse effects of transcutaneous electrical nerve stimulation (TENS) for ameliorating pruritus in patients with dermatoses. METHOD...

Perilla (Perilla frutescens L.) leaves have shown therapeutic efficacy in the treatment of inflammatory disorders, allergies, bronchial asthma, and systemic damage due to free radicals. In the present study we analyzed the active constituents in perilla leaves using high-performance liquid chromatography (HPLC) and isolated luteolin, a polyphenolic flavonoid. We investigated the anti-inflammato...