Fordecades, the standardprocedurewhen screening for candidate anticancer drug combinations hasbeen to search for synergy, defined as any positive deviation from trivial cases like when the drugs are regarded as diluted versions of each other (Loewe additivity), independent actions (Bliss independence), or no interaction terms in a response surface model (no interaction). Here, we show that this...

Purpose. Perivascular epithelioid cell tumors (PEComas) are a rare collection of tumors characterized by a myomelanocytic phenotype, and PEComas occurring in "nonclassic" anatomic distributions are known as perivascular epithelioid cell tumor not otherwise specified (PEComa-NOS). This review aims to compile and analyze cases of PEComa-NOS in an effort to better define their natural history. Des...

The survival rates of children treated for cancer have dramatically increased after the development of standardized multiple-modality treatment protocols. As a result, there is a rapidly growing population of pediatric cancer survivors in which the long-term genotoxic effects of chemotherapeutic intervention is unknown. To study the genotoxic effects of antineoplastic treatment in children, we ...

OBJECTIVES The aim of the preset study was to evaluate the applicability of a closed system device to protect against occupational contamination and exposure to antineoplastic drugs in the work environment of a hospital. METHODS We compared the contamination by and exposure to cyclophosphamide (CPA) between a conventional mixing method and a mixing method using a closed system device. Wipe sa...

Diameter Extensible Authentication Protocol (EAP) Application draft-ietf-aaa-eap-06.txt Status of this Memo By submitting this Internet-Draft, I certify that any applicable patent or other IPR claims of which I am aware have been disclosed, and any of which I become aware will be disclosed, in accordance with RFC 3668. Internet-Drafts are working documents of the Internet Engineering Task Force...

This document describes an Extensible Provisioning Protocol (EPP) mapping for the provisioning and management of Internet domain names stored in a shared central repository. Specified in XML, the mapping defines EPP command syntax and semantics as applied to domain names. This document obsoletes RFC 4931.

Cancer prehabilitation, a process on the continuum of care that occurs between the time of cancer diagnosis and the beginning of acute treatment, includes physical and psychological assessments that establish a baseline functional level, identifies impairments, and provides targeted interventions that improve a patient's health to reduce the incidence and the severity of current and future impa...

IN 1974, SHORTLY AFTER PRESIDENT Nixon had called for a “War Against Cancer,” Mary Lasker, patroness and advocate of clinical research, at a meeting of the President’s Cancer Panel, asked the National Cancer Institute to publish a book, to be updated every 6 months, listing all ongoing cancer treatment protocols in the United States. The idea was that physicians would be able to identify open t...

BACKGROUND Biological and some clinical evidence suggest that high-dose intravenous vitamin C (IVC) could increase the effectiveness of cancer chemotherapy. IVC is widely used by integrative and complementary cancer therapists, but rigorous data are lacking as to its safety and which cancers and chemotherapy regimens would be the most promising to investigate in detail. METHODS AND FINDINGS W...