Peptides with potent broad-spectrum antibiotic activity have been identified in many animal species. Recent investigations have demonstrated that epithelial cells are a site of antibiotic peptide expression, suggesting that these peptides contribute to host defense at mucosal surfaces. Expression of tracheal antimicrobial peptide (TAP), a member of the beta-defensin family of peptides, is induc...

one of the great challenges in the treatment of infectious diseases is the resistance of pathogenic bacteria against antibiotics, and antibiotic resistance to shigella is broadly observed in different parts of the world. the object of this study was to determine shigella antibiotic resistance pattern against the antibiotics such as ampicillin, amoxicillin, trimethoprim-sulfamethoxazole, chloram...

surgical site infections are one of the most important post-surgery complications. antimicrobial prophylaxis has been used routinely in surgeries to reduce infection incidence. however, inappropriate selection of antimicrobial agents or dosing can develop antimicrobial resistance, serious adverse reactions and prolong hospitalization. current study aimed to examine prophylactic antibiotic presc...

background and objectives: shigella plays an important role as a causative organism of acute gastroenteritis, in children and others. rapid emergence of antibiotic resistance warrants continuous monitoring of susceptibility pattern of bacterial isolates. we report here our findings about shigella spp. isolates and their drug resistance patterns in nepalese patients. materials and methods: the s...

background: although various surface disinfectants have been introduced, most of them are toxic. the use of natural antimicrobial agent e.g. phytol, extracted from leptadenia pyrotechnica is a new strategy. the aim of this study was to evaluate the antimicrobial activity, toxicity, and stability of phytol. methods: the serial concentrations of phytol were prepared, and separately incubated with...

conclusions: the results showed that silver nanoparticles have an antimicrobial effect against intramacrophage b. abortus 544. results: the well diffusion agar study showed that silver nanoparticles have an antimicrobial effect on b. abortus 544. the mic and mbc of silver nanoparticles against b. abortus 544 were; 6 ppm and 8 ppm, respectively. the silver nanoparticles showed antibacterial effe...

the antimicrobial activity of methanolic extracts from different parts of 11 indigenous wild plantspecies used in traditional medicines of iran were tested against nine species of microorganisms: escherichiacoli, staphylococcus aureus, staphylococcus epidermis, pseudomonas aeruginosa, klebsiella pneumoniae,salmonella typhi, bacillus subtilis, aspergillus niger and candida albicans. the antimicr...

substituted schiff bases (hydrazones) 5a-j have been prepared from the starting material 2-chloro pyridine-3-carboxylic acid 1 by a sequence of reactions like reaction with 2-amino-6-nitro benzothiazole (ullamann condensation), thionyl chloride, hydrazine hydrate and different aromatic aldehydes. on cyclocondensation of 5a-j with thioglycolic acid in dry 1,4-dioxane furnished desired compounds ...

a series of n-substituted-2,4-thiazolidinedione derivatives (tzds) were prepared via n-alkylation of 2,4-tzd at position 3 using substituted benzyl halides. synthesized n-substituted-2,4-tzd was then substituted at position 5 with substituted aromatic aldehyde according to knoevenagel condensation method. structures of the compounds were elucidated using various spectral techniques viz. ir, 1hn...