antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (cq) and amodiaquine (aq), have been used to prevent and treat malaria for many years. the importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. in recent years, with the spread of parasite resistance to cq and cross-resist...

The investigation of Thai medicinal plants for the potential therapeutic agents is surveyed with a particular emphasis on the search for antimalarial agents. The study on Diospyros mollis, Croton sublyratus, and Phyllanthus amarus is described. Thailand is uniquely located to represent the fauna and flora which characterizes the biogeographic province of Indo-Burma. A number of the eastern Hima...

The formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. In this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. Fifteen extracts with different polarity from three Iranian Artemisia species, A. ciniformis, A. biennis an...