The present study aimed at investigating physicochemical changes in modified LDL by sugars specifically fructose due to recent reports on its involvement in cardiovascular diseases and also glucose and their role in subsequent in vitro accumulation of cholesterol in macrophages. Antiglycation action of aminoguanidine was also investigated. LDL isolated from human blood was incubated with fructo...

Diabetes is a severely debilitating metabolic disorder characterised by chronic hyperglycaemia. Traditional medicinal plants provide an important avenue for the development of novel antidiabetic agents. The antidiabetic potential of the methanol, acetone, and hexane extracts of S. plumosum was assessed using different parameters. These included secondary metabolite quantification, hypoglycaemic...

Glycation, or nonenzymatic glycosylation, is a chemical reaction between reactive carbonyl-containing compounds and biomolecules containing free amino groups. Carbonyl-containing compounds include reducing sugars such as glucose or fructose, carbohydrate-derived compounds such as methylglyoxal and glyoxal, and nonsugars such as polyunsaturated fatty acids. The latter group includes molecules su...

the aim of this study was to assess the antiglycation and antioxidant properties of aqueous extract of anethum graveolens (dill). in the in vivo and in vitro experiments, antioxidant properties, blood glucose, and ages formation were determined. dill extract was given orally to healthy and diabetic rats. our results illustrated that different concentrations of dill extract (0.125, 0.25, 0.5, an...

A novel polysaccharide fraction (BCP-1) was extracted from the black currant fruit by ultrasound-assisted compound enzyme and purified by chromatography on macroporous resin D4006, anion-exchange Q-Sepharose FF and Sephadex G-100 columns. BCP-1 consisted of galacturonic acid, xylose, mannose, glucose and galactose in a ratio of 1.00:3.14:1.83:17.90:1.98 and its molecular weight was 14,050 Da. T...

The extent of glycation of human eye lens proteins with glucose in presence of added inositol was examined in vitro using [U14C] glucose. Lens homogenate was reacted with varying concentrations of glucose and glucose + inositol. At the end of the reaction, the proteins were precipitated with TCA, centrifuged, dissolved in NaOH and the radioactivity was measured. Inositol decreased the glycation...

Abstract When glucose and Amadori products are auto-oxidized, glycation occurs, resulting in the formation of early (Amadori) late advanced end (AGEs), as well free radicals. Glycation an increase radical activity induce diabetic complications. Antioxidant antiglycation compounds may aid prevention oxidation glycation. The goal this study was to assess antioxidant capacity C-phycocyanin (C-PC) ...

BACKGROUND Glycation is an aging reaction of naturally occurring sugars with dermal proteins. Type I collagen and elastin are most affected by glycation during intrinsic chronological aging. AIM To study the in vitro and ex vivo assays in human skin cells and explants and the antiaging effects of glycylglycine oleamide (GGO). MATERIALS AND METHODS The antiglycation effect of GGO was assesse...