نتایج جستجو برای: antigenic seed

تعداد نتایج: 95806  

Journal: :Computer applications in the biosciences : CABIOS 1988
B. A. Jameson H. Wolf

In this paper, we introduce a computer algorithm which can be used to predict the topological features of a protein directly from its primary amino acid sequence. The computer program generates values for surface accessibility parameters and combines these values with those obtained for regional backbone flexibility and predicted secondary structure. The output of this algorithm, the antigenic ...

Journal: :Statistics in medicine 2018
Gabriela B Cybis Janet S Sinsheimer Trevor Bedford Andrew Rambaut Philippe Lemey Marc A Suchard

Influenza is responsible for up to 500,000 deaths every year, and antigenic variability represents much of its epidemiological burden. To visualize antigenic differences across many viral strains, antigenic cartography methods use multidimensional scaling on binding assay data to map influenza antigenicity onto a low-dimensional space. Analysis of such assay data ideally leads to natural cluste...

2017
Yousong Peng Dayan Wang Jianhong Wang Kenli Li Zhongyang Tan Yuelong Shu Taijiao Jiang

Rapid determination of the antigenicity of influenza A virus could help identify the antigenic variants in time. Currently, there is a lack of computational models for predicting antigenic variants of some common hemagglutinin (HA) subtypes of influenza A viruses. By means of sequence analysis, we demonstrate here that multiple HA subtypes of influenza A virus undergo similar mutation patterns ...

Journal: :Journal of virology 2013
Jaclyn L Myers Katherine S Wetzel Susanne L Linderman Yang Li Colleen B Sullivan Scott E Hensley

Influenza viruses routinely acquire mutations in antigenic sites on the globular head of the hemagglutinin (HA) protein. Since these antigenic sites are near the receptor binding pocket of HA, many antigenic mutations simultaneously alter the receptor binding properties of HA. We previously reported that a K165E mutation in the Sa antigenic site of A/Puerto Rico/8/34 (PR8) HA is associated with...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Arthur Chun-Chieh Shih Tzu-Chang Hsiao Mei-Shang Ho Wen-Hsiung Li

The HA1 domain of HA, the major antigenic protein of influenza A viruses, contains all of the antigenic sites of HA and is under continual immune-driven selection. To resolve controversies on whether only a few or many residue sites of HA1 have undergone positive selection, whether positive selection at HA1 is continual or punctuated, and whether antigenic change is punctuated, we introduce an ...

2009
Jie Dong Yumiko Matsuoka Taronna R. Maines David E. Swayne Eduardo O’Neill C. Todd Davis Neal Van‐Hoven Amanda Balish Hong‐jie Yu Jacqueline M. Katz Alexander Klimov Nancy Cox De‐xin Li Yu Wang Yuan‐ji Guo Wei‐zhong Yang Ruben O. Donis Yue‐long Shu

BACKGROUND Highly pathogenic H5N1 avian influenza viruses currently circulating in birds have caused hundreds of human infections, and pose a significant pandemic threat. Vaccines are a major component of the public health preparedness for this likely event. The rapid evolution of H5N1 viruses has resulted in the emergence of multiple clades with distinct antigenic characteristics that require ...

Journal: :Bulletin of mathematical biology 2012
Konstantin B Blyuss Yuliya N Kyrychko

Effects of immune delay on symmetric dynamics are investigated within a model of antigenic variation in malaria. Using isotypic decomposition of the phase space, stability problem is reduced to the analysis of a cubic transcendental equation for the eigenvalues. This allows one to identify periodic solutions with different symmetries arising at a Hopf bifurcation. In the case of small immune de...

Journal: :Acta tropica 1977
B Schläppi L Jenni

Antigenic variants of T. congolense transmitted by G. m. morsitans through normal and X-irradiated mice were investigated by means of the neutralization test and IFAT. Clones of a cyclically passaged derivative strain were isolated from irradiated and normal mice. The IFAT revealed cross immunofluorescent reactions between most of the stabilates, whereas only the two clones obtained from irradi...

Journal: :Infection and immunity 1975
D Bratthall R J Gibbons

Strains of Streptococcus mutans representative of serotypes b and d exhibited antigenic variation in both the oral cavity and in the intestinal canal of gnotobiotic rats. Laboratory-maintained cultures did not vary. The antigenic alterations observed were: (i) loss of detectable levels of both weakly reacting "strain" antigens and the type antigen; (ii) decreased production of the type antigen;...

Journal: :Journal of bacteriology 2010
R Allen Helm H Steven Seifert

The rates of pilin antigenic variation (Av) of two strains of Neisseria meningitidis were determined using an unbiased DNA sequencing assay. Strain MC58 underwent pilin Av at a rate similar to that of N. gonorrhoeae strain MS11 but lower than that of N. gonorrhoeae strain FA1090. Pilin Av was undetectable in strain FAM18.

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