Previous studies have shown that administration of riboflavin, vitamin B2, significantly reduced edema formation following experimental stroke. The present study evaluated the ability of B2 to improve behavioral function, reduce edema formation, and limit glial fibrillary acidic protein (GFAP) expression following frontal cortex contusion injury. Groups of rats were assigned to B2 (7.5 mg/kg) o...

The cellular and molecular mechanisms governing bradykinin B1 and B2 receptor expression and function are poorly understood. We investigated the regulation of both B1 and B2 receptors in human embryonic lung fibroblasts (HEL 299) by the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta). TNF-alpha and IL-1beta both induced a rapid and transient in...

The interfacial structures and behaviors are critical in determining the material properties. Our study aims to investigate such unique multiphase systems involving complex compositions. Herein, we report divergent of L12–L12, B2–B2, L12–B2 boundaries prepared via bonding AlCoCrFeNi2.1 eutectic high-entropy alloys (HEAs). Specifically, dynamic recrystallization (DRX) occurs L12–L12 boundary owi...

The present study was performed to: (a) evaluate the effects of kinin B1 (Sar[D-Phe8]-des-Arg9-BK; 10 nmol/kg) and B2 (bradykinin (BK); 10 nmol/kg) receptor agonists on plasma extravasation in selected rat tissues; (b) determine the contribution of a lipopolysaccharide (LPS) (100 microg/kg) to the effects triggered by B1 and B2 agonists; and (c) characterize the selectivity of B1 ([Leu8]desArg9...

parent ACsEx.A Concrete children ACsEx.B1, ACsEx.B2, ACsEx1.B3 Class ACsEx.B1: Inherited methods B1.a2(), B1.a3(), B1.a4(P), B1.a7() Class ACsEx.B2: Inherited methods B2.a1(P), B2.a4(P), B2.a6(), B2.a7(), B2.a8(int) Class ACsEx1.B3: Inherited methods B3.a4(P), B3.a6(), B3.a7(), B3.a8(int) for the classes ACsEx.A, ACsEx.B1, ACsEx.B2, and ACsEx1.B3 from the code in Figure 1, the data in Table IV ...

5,442,672 A * 8/1995 Bjorkholm et al. ............. .. 378/4 6,103,350 A * 8/2000 Grangeat et al. ......... .. 428/1951 6,507,633 Bl 1/2003 Elbakri et 31. 6,754,298 B2 6/2004 Fessler 6,768,782 B1 7/2004 Hsieh et al. 6,850,585 B2 2/2005 Hsieh et al. 6,907,102 B1 * 6/2005 Sauer et al. ................... .. 378/19 7,103,204 B1 * 9/2006 Celler et al. ................ .. 382/131 7,221,728 B2 5/2007...

Let G be a graph, u be a vertex of G, and B(u)(or BG(u)) be the set of u with all its neighbors in G. A sequence (B1, B2, ..., Bn) of subsets of an n-set S is a neighborhood sequence if there exists a graph G with a vertex set S and a permutation (v1, v2, ..., vn) of S such that B(vi) = Bi for i = 1, 2, ..., n. Define Aut(B1, B2, ..., Bn) as the set {f : f is a permutation of V (G) and (f(B1), ...

Glomerular development proceeds through the spatially ordered and sequential recruitment, proliferation, assembly, and differentiation of endothelial, mesangial, and epithelial progenitors. The molecular determinants of cell-cell recognition and targeting in this process have yet to be defined. The Eph/ephrin family of membrane receptors and counter-receptors are critical participants of develo...

A few reports were found on the riboflavin (B2) in the eye tissues in various species (1-3). Flavin compound in the eye of Rana nigromaculata concentrates in the choroid, iris, ciliary body and is not present in other parts. The amount and distribution of flavin compound in the eye varies considerably in different species of frogs (4). The presence of B2 in the lens of haddock (Gadus aeglefinus...

Two B-type cyclins, B1 and B2, have been identified in mammals. Proliferating cells express both cyclins, which bind to and activate p34(cdc2). To test whether the two B-type cyclins have distinct roles, we generated lines of transgenic mice, one lacking cyclin B1 and the other lacking cyclin B2. Cyclin B1 proved to be an essential gene; no homozygous B1-null pups were born. In contrast, nulliz...