Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties. Recommended over-the-counter doses (range = 2-8 mg daily) do not produce opioid effects in the central nervous system because of poor oral bioavailability and P-glycoprotein efflux* of the medication (1); recent reports suggest that large doses (50-300 mg) of loperamide produce euphoria, central nervous sys...

Fecal incontinence is a debilitating and common problem with a profound effect on a patient's well being medically, socially, and economically. Non-operative management of this condition includes dietary modification, antidiarrheal medications, and biofeedback. Patients with severe incontinence can be divided into 2 categories. The first group includes patients with an identifiable and isolated...


 Backround: Diarrhoea is a condition characterised by watery, loose stools that occurs more than three times daily. In Indonesian traditional medicine, salam leaves and jackfruit have been used as herbal treatments for many conditions, including antidiarrheal medicines. Aims: The aim of this experimental study was to evaluate the effect combination Salam infusum induced castor oil in rats...

Eosinophilic enteritis (EOE) is a type of inflammatory bowel disease and is characterized clinically by chronic obstinate diarrhea. Three Japanese Black (JB) fattening cattle (2 males and 1 female) on different cattle farms presented with chronic episodic diarrhea without fever or dehydration. Soft reddish spherical carneous tissues (1-3 cm) were occasionally excreted within the diarrheic feces...

Secretory diarrhea occurs when the balance between intestinal absorption and secretion is disturbed by excessive secretion caused by enterotoxins produced by the pathogen. Wood creosote has long been used as a traditional antidiarrheal remedy. The goal of our study was to extend our knowledge about the antisecretory action of wood creosote against Escherichia coli enterotoxin-induced secretion ...

Plinia cauliflora (Mart.) Kausel, widespread in South America, has edible fruits, and its bark is commonly used against diarrhea and other disorders, on account of its astringency. Because diarrhea is still one of the most important causes of illness and death among children in developing countries, where the population turns to traditional medicine for its treatment, the present study determin...

Sesquiterpene lactones (SLs) are a group of secondary metabolites that represent a diverse and unique class of natural products and are important constituent of essential oils, formed from head-to-tail condensation of three isoprene units and subsequent cyclization and oxidative transformation to produce a cis or trans-fused lactone. In this editorial we are going to focus on anticancer, anti-i...

Table 1. Symptom – Based Treatment of Irritable Bowel Syndrome Pain Predominant Diarrhea Predominant Constipation Predominant Antispasmodic Agents  Dicycloverine (Bentyl)  Mebeverine Tricyclic Antidepressants  Amitriptyline Antidiarrheal Agents  Loperamide (Imodium)  Cholestyramine (questran) Serotonin (5-HT3) antagonist  Alosetron (Lotronex)  Ondansetron (Zofran) Serotonin (5-HT4) Agoni...

1. Recognize the electrolyte changes associated with isotonic dehydration. 2. Effectively manage a child who has isotonic dehydration. 3. Understand the importance of early feedings on the nutritional status of a child who has gastroenteritis. 4. Fully understand that antidiarrheal agents are not indicated nor recommended in the treatment of acute gastroenteritis in children. 5. Recognize the r...