Dear Editor: Extensive studies have measured antidepressant-like effects of chemical compounds to discover new drugs for depression treatment or to clarify the molecular mechanisms of depression. Most useful anti-depressants including tricyclics, selective serotonin reuptake inhibitors (SSRIs), noradrenaline reuptake inhibitors (NRIs), serotonin and noradrenaline re-uptake inhibitors (SNRIs), a...

Leishmaniasis is one of the most diverse and complex vector-borne metazoonosis diseases[1]. The causing agent is at least 17 species[2] of obligate intracellular protozoan parasites that belong to the genus Leishmania[3]. It is transmitted to human by the bite of phlebotomine female sand flies of the genera Phlebotomus and Lutzomyia in the old and new worlds respectively[4]. The species are in ...

Although depressive disorders have been known for centuries, drug treatment is relatively recent. It was only in the 1950s, when studyof a drug for tuberculosis, Iproniazid, that its antidepressant propertieswere identified. After 50 years more selective and specific drugs have been discovered. The authors review not only new realities in depressive psychopathology, but also the latest innovati...

BACKGROUND AND PURPOSE Depression after stroke is often described as underdiagnosed and undertreated. However, there are few data on self-reported depression and use of antidepressants in stroke patients at large. MATERIALS AND METHODS In the Swedish national quality assessment register, Riks-Stroke, 15 747 stroke survivors are recorded. They were asked about depressive mood and antidepressan...

Aim: Hyoscyamus niger (Solanaceae) has been used for treatment of mental disorders, epileptic mania, chronic dementia with insomnia. However, it is not yet studied in condition like depression. The present study was planned with an objective to evaluate its antidepressant like property in animal models of depression and to find out the possible mechanism underlying this action in mouse model of...

WHAT IS KNOWN AND OBJECTIVE Abundant clinical data now confirm that ketamine produces a remarkable rapid-onset antidepressant effect - hours or days - in contrast to the delayed onset (typically weeks) of current antidepressant drugs. This surprising and revolutionary finding may lead to the development of life-saving pharmacotherapy for depressive illness by reducing the high suicide risk asso...

Cheeta Cheeta et al et al (2004) present data on (2004) present data on antidepressant-related deaths in England antidepressant-related deaths in England and Wales, 1998–2000. They report in-and Wales, 1998–2000. They report information about antidepressant deaths formation about antidepressant deaths collected by the National Programme of collected by the National Programme of Substance Abuse ...

OBJECTIVE To examine inhospital mortality and morbidity associated with self-poisoning with different drug classes over an extended period. DESIGN, SETTING AND PARTICIPANTS A prospective cohort study over 26 years (1987-2012) with limited follow-up of patients presenting consecutively to a primary and tertiary referral toxicology centre covering Newcastle, Lake Macquarie and Port Stephens, Au...