The analgesic efficacy of cholinergic agonists and anticholinesterase agents has been widely recognized. The analgesic effect obtained by activating cholinergic mechanisms, however, seems to depend on the experimental pain model utilized for its evaluation. The antinociceptive effect of intraspinal neostigmine was examined in rats submitted concurrently to the tail flick and formalin tests. Neo...

The interest in octamethylpyrophosphoramide (schradan) as a systemic insecticide (l-3) and in the treatment of myasthenia gravis (4) emphasizes the need for a better understanding of its mode of toxic action. Exposure of mammals to schradan leads to death, with the typical symptoms of acetylcholine poisoning after a definite lag period (5, 6). Yet schradan is only about one-millionth as effecti...

BACKGROUND Anticholinesterase therapies offer modest benefit to subgroups of AD sufferers. However, there has previously been no way of predicting which patients will respond to any of the drugs. OBJECTIVE To discover if gender and/or apolipoprotein E genotype can be used as predictors of response in the clinical setting. DESIGN 107 patients from the Bristol Memory Disorders Clinic took par...

The species of the genus Rauvolfia are a reservoir indole alkaloids with proven pharmacological properties. A chloroform extract root bark vomitoria (Apocynaceae) was studied. phytochemical investigation said allowed isolated four indolic alkaloids, three which known (Reserpine, ajmaline and mauiensine) unknown phyto-constituent (3). In addition, methyl esters 3, 4, 5-trimethoxybenzoic acid (Ph...

The present study investigates the antioxidant, anticancer, anticholinesterase, anti-genotoxic activities and phenolic contents of flower, fruit and seed methanol extracts of Hypericum retusum AUCHER. The amounts of protocatechuic acid, catechin, caffeic acid and syringic acid in methanol extracts were determined by HPLC. Total phenolic content of H. retusum seed extract was found more than fru...