OBJECTIVES To compare the effect of using different anticholinergic drug scales and different models of cognitive decline in longitudinal studies. DESIGN Longitudinal cohort study. SETTING Outpatient clinics, Quebec, Canada. PARTICIPANTS Individuals aged 60 and older without dementia or depression (n = 102). MEASUREMENTS Using baseline and 1-year follow-up data, four measures of anticho...

BACKGROUND AND PURPOSE Oromandibular dyskinesia (OMD) can occur spontaneously or they can be induced by the conventional dopamine receptor antagonists. Anticholinergic medications have rarely been reported to cause OMD in parkinsonian or non-parkinsonian patients. METHODS We analyzed the clinical features of two parkinsonian and one non-parkinsonian patients who experienced OMD after antichol...

We report 2 cases of teenagers who were poisoned with Jimson weed (Datura stramonium) and presented to the emergency department with a severe acute anticholinergic toxidrome after ingestion of several hundred seeds. The patients presented with visual hallucinations, disorientation, incomprehensible and nonsensical speech, and dilated sluggish pupils. Both patients required restraints for combat...

We review the utility of serum anticholinergic activity (SAA) as a peripheral marker of anticholinergic activity (AA) in the central nervous system (CAA). We hypothesize that the compensatory mechanisms of the cholinergic system do not contribute to SAA if their system is intact and that if central cholinergic system deteriorates alone in conditions such as Alzheimer's disease or Lewy body deme...

Gastric secretion was stimulated by insulin hypoglycaemia and the effect of increasing doses of anticholinergic drugs on the volume, acid, and electrolyte content of gastric juice was studied. The sodium and potassium output was depressed to a far less extent than the acid output and the drop in volume of secretion and acid output after anticholinergic drugs is almost entirely due to decreased ...

OBJECTIVE To review the efficacy of drug therapy for urinary urge incontinence by examining the published literature. METHODS OF STUDY SELECTION In October 1999, we searched the medical databases MEDLINE, EMBASE, and Cochrane Controlled Trials Register to identify prospective randomized, double-blind, placebo-controlled clinical trials in the English literature evaluating drug therapy (except...

Purpose: False-negative urodynamic findings may mislead or prevent planned treatments due to unmatched with the clinical presentation. We hypothesized that absence of demonstration SUI OAB on urodynamics would interfere outcomes. Materials and Methods: prospectively studied 124 women (94) without (30) demonstrable after sling operations. Similarly, 64 syndrome (38) (26) DO were also compared tr...

The mainstay of pharmacologic treatment of overactive bladder is anticholinergic therapy. Cholinergic blockade is efficacious in decreasing the symptoms of urgency, frequency, and urge incontinence, but also is associated with undesirable side effects such as dry mouth, blurred vision, constipation, and central nervous system side effects. The property of anticholinergic agents that has been as...