Candida albicans remains the main etiologic agent of candidiasis, the most common fungal infection and now the third most frequent infection in U.S. hospitals. The scarcity of antifungal agents and their limited efficacy contribute to the unacceptably high morbidity and mortality rates associated with these infections. The yeast-to-hypha transition represents the main virulence factor associate...

Increasing bacterial resistance to available antibiotics makes the discovery of novel efficacious antibacterial agents a priority. A previous report showed that listeriolysin O (LLO) is a critical virulence factor and suggested that it is a target for developing anti-virulence drugs against Listeria monocytogenes infections. In this study, we report the discovery of LLO natural compound inhibit...

Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor virulence factors to the cell wall. Here we review what is known about the mechanism of sortase mediated protein anchoring and discuss recently identified inhibitors of this new important enzyme family.

Qualitative immunological differences exist between early passage strains or so called human strains of the virus of poliomyelitis. These differences show a relationship to the epidemic source of the virus and are exemplified in this study by 4 strains isolated in different years during an eastern and western epidemic of poliomyelitis.

During the past 5 years we have collected 6 strains of the virus of poliomyelitis and we have observed certain characteristics which differentiate some from the others. Two of these strains (namely those isolated in New York and Connecticut in 1931) have already been compared with another pair of them representing more widely known strains of the virus (1). I t has seemed justifiable, however, ...

Abstract With the increase of crewed space missions and rise microbiology, research microbes grown under microgravity environment has been attracting more attention. The scope in microbiology extended beyond pathogens directly related to spaceflight. Y. pestis , causative agent plague, is also interest researchers. After being cultivated for 40 consecutive passages either simulated (SMG) or nor...

Yersinia pestis, the causative agent of plague, encodes several essential virulence factors on a 70 kb plasmid, including the Yersinia outer proteins (Yops) and a multifunctional virulence antigen (V). V is uniquely able to inhibit the host immune response; aid in the expression, secretion, and injection of the cytotoxic Yops via a type III secretion system (T3SS)-dependent mechanism; be secret...

Guduchi is a plant also known as Tinospora cordifolia, having heart shaped leave, an herb of the family Menispermaceae native hot areas Indian subcontinent. In our classical Ayurvedic texts, it indicated to be beneficial in treating various types diseases like skin disorders, different fever, jaundice & gout. claimed have properties anti-oxidant, antihyperglycemic, antihyperlipidemic, hepat...