Mycobacterium tuberculosis is the major pathogen of tuberculosis (TB). With the growing problem of M. tuberculosis resistant to conventional antibiotics, especially multi-drug resistant tuberculosis (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB), the need for new TB drugs is now more prominent than ever. Among the promising candidates for anti-TB drugs, anti-mycobacterial peptide...

Tuberculosis remains one of the causes death from a single infectious bacterium. The inappropriate use antibiotics and patients’ non-compliance among other factors drive emergence drug-resistant tuberculosis. Multidrug-resistant extensively strains tuberculosis pose significant challenges to current treatment regimens, as their reduced efficacy against these limits successful patient outcomes. ...

A quantitative structure activity relationship study was performed on different groups of anti-tuberculosis drug compound for establishing quantitative relationship between biological activity and their physicochemical /structural properties. In recent years, a large number of herbal drugs are promoted in treatment of tuberculosis especially due to the emergence of MDR (multi drug resistance) a...

Objective: To determine the anti-tuberculosis drugs effect on lipid profile parameters in pulmonary tuberculosis (TB) patients.Methods: A prospective cross-sectional study was conducted at Tehsil Headquarter Hospital, Taunsa Sharif and District Teaching Dera Ghazi Khan from December 2020 to May 2021. The blood samples 84 positive TB patients were collected three different intervals of study, be...

What methods would you choose apart from purified protein derivative (PPD) skin test and culture for acid-fasting bacilli (AFB) to make a clinical diagnosis of pulmonary tuberculosis (TB) in an aged patient with possible TB? These are two cases TB, that occurred persistent low-grade fever, fatigue anorexia due mild toxemia tuberculosis. A final was established on the basis toxemia(low-grade fev...

Endobronchial tuberculosis (EBTB) is defined as (TB)infection of the tracheobronchial tract. Tracheal and bronchial involvement from TB infection was first reported by Morten in 1698. a form that difficult to diagnose because lesions are frequently undetectable sputum examination chest X-ray alone. present 10-40% active patients more than 90% cases accompanied stenosis various degrees. The main...

Tuberculosis is an infectious airborne disease caused by a bacterial infection that affects the lungs and other parts of the body. Vaccination against tuberculosis is available but proved to be unsuccessful against emerging multi drug and extensive drug resistant bacterial strains. This in turn raises the pressure to speed up the research on developing new and more efficient anti-tuberculosis d...

The objective: to identify factors influencing the development of dyspepsia in children during treatment with anti-tuberculosis drugs. Results: out 243 chemotherapy, 22.6% developed as an adverse reaction. Risk significantly associated were follows: formula feeding at birth, comorbidities gastrointestinal tract, decreased total protein and elevated leukocyte counts by admission hospital, tuberc...