Prion diseases are associated with the conformational conversion of the physiological form of cellular prion protein (PrP(C)) to the pathogenic form, PrP(Sc). Compounds that inhibit this process by blocking conversion to the PrP(Sc) could provide useful anti-prion therapies. However, no suitable drugs have been identified to date. To identify novel anti-prion compounds, we developed a combined ...

UNLABELLED BACKGROUND Benzimidazole derivatives are structurally bioisosteres of naturally occurring nucleotides, which makes them compatible with biopolymers of living systems. This property gives benzimidazole a biological and clinical importance. In the last decade, this class of compounds has been reported to possess anti-allergic, anti-diabatic, anti-HIV, anti-hypertensive, anti-inflamm...

In present study novel series of benzothiazole derivatives were synthesized and their anti cancer efficacy was analyzed using cancer cell lines (Human Chronic Myelogenous Leukemia). The compounds were synthesized by simple and facile procedures and characterized by IR, H-NMR and Mass spectra study. The synthesized compounds were screened for anti cancer activity using in vitro assays. The compo...

A series of 2-mercaptobenzimidazole derivatives (MB1–MB5) were synthesized by mannich reaction. The purity of synthesized compounds were determined by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. The newly synthesized compounds were screened for anti-inflammatory activities on carrageenan induced paw oedema in ...

The Eupatorium plant has been well used in medication and as a decorative plant. Some studies have reported that this herb biochemical compounds, such sesquiterpenes, phenolics, polysaccharides, pyrrolizidine alkaloids. Thus, it pharmacological effects, including antifungal, antibacterial, cytotoxic, antinociceptive properties, can be utilized for cosmetic purposes. However, only few published ...

phenolic and flavonoid compounds are secondary metabolites of plants which possess various activities such as anti-inflammatory, analgesic, anti-diabetes and anticancer effects. it has been established that these compounds can scavenge free radicals produced in the body. because of this ability, not only the plants containing phenolic and flavonoid compounds but also, the pure compounds are use...

Chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. In the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and Wistar rats by using the writhing and formalin-induced paw edema tests respectively. The activities of the compounds were compared with celecoxib as a referenc...

Background: Artemisia dracunculus L. belongs to the Anthemideae tribe of Asteraceae family. This plant has been used in traditional folk medicine. Also, it's anti-bacterial, anti-fungal, antioxidant, anti-inflammatory and hepatoprotective activity has been proved. Objective: The purpose of this study was to evaluate the antioxidant activity of leaves and inflorescence of A. dracunculus and als...

− Eight isoflavonoid compounds were isolated from the EtOAc fraction of Maackia amurensis which had shown the highest anti-Helicobacter pylori activity among the fractions, using medium pressure liquid chromatography and recrystallization. Based on the spectroscopic data including H-NMR, C-NMR, HMBC and MS data, the chemical structures of the isolates were determined to be (−)-medicarpin (1), a...

ETHNOPHARMACOLOGICAL RELEVANCE The bark of Cinnamomum cassia, called 'Rou-Gui', a traditional spice and medicine in China, is used to treat diseases resulted from kidney yang deficiency, including diabetic nephropathy. The aim of this study is to investigate the anti-diabetic nephropathy activity of Rou-Gui and the active compounds in it. MATERIALS AND METHODS The air-dried bark of C. cassia ...