three major flavonoid fractions were separated from a methanol extract of calendula officinalis flowers by preparative tlc. these fractions were evaluated for the inhibition of parent and tamoxifen resistant t47d human breast cancer cells. we also examined the effect of quercetin and isorhamnetin on the growth of parent and resistant t47d cells in the presence and absence of tamoxifen. it was f...

BACKGROUND Melicope ptelefolia is a well-known herb in a number of Asian countries. It is often used as vegetable salad and traditional medicine to address various ailments. However, not many studies have been currently done to evaluate the medicinal benefits of M. ptelefolia (MP). The present study reports antioxidant, anti-proliferative, and apoptosis induction activities of MP leaf extracts....

Biological activities of various mushrooms have recently been discovered, particularly, immunomodulatory and antitumor activities. Herein, three edible mushrooms, Auricularia auricula-judae (AA), Pleurotus abalonus (PA) and Pleurotus sajor-caju (PS) extracted using Soxhlet ethanol extraction were evaluated for their antioxidative, anti-proliferative effects on leukemia cells. Using the Folin-Ci...

Objective(s): Juglone is isolated from many species of the Juglandaceae family and used as an anti-viral, anti-bacterial, and anti-tumor therapeutic. Here, we evaluated juglone-induced antitumor effect in ovarian cancer SKOV3 cells. Materials and Methods: MTT assay was performed to examine juglone anti-proliferative effect. Cell cycle and apoptosis were studied using flow cytometry in juglone-t...

Three near-infrared (NIR-I) optical theranostic systems were synthesized, characterized and studied in vitro vivo. These original homo-bimetallic gold(I)-based aza-BODIPY complexes proved to be trackable through imaging cells mice. They display anti-proliferative properties micromolar range against human murine cancer cell lines (4T1, MDA-MB-231, CT26, SW480). Moreover, the injection of most pr...

The Present study attempts to determine the relationship between proliferation and inhibition of apoptosis in normal endometrium hyperplasia, using monoclonal antibodies against marker, Ki-67 anti-apoptotic protein, Bcl-2 expression B-cell lymphoma 2 (Bcl – 2) Ki 67 cyclical proliferative secretory phase. includes Bcl endometrial hyperplasia.

BACKGROUND Natural products obtained from plants can be potent sources for developing a variety of pharmaceutical products. Allium species have been widely studied for their anti-cancer effects and presented promising results as potential anti-cancer agents. Breast cancer (BCa) is one of the most commonly diagnosed types of cancer in women. In this study, we aimed to investigate the anti-prolif...

5.1.1 Overall, high doses of metformin reliably reduced proliferation and migration. 41 5.1.2 Susceptibility to metformin's anti-proliferative and anti-migratory action varied

A group of styrylquinolines were synthesized and tested for their anti-proliferative activity. Anti-proliferative activity was evaluated against the human colon carcinoma cell lines that had a normal expression of the p53 protein (HCT116 p53+/+) and mutants with a disabled TP53 gene (HCT116 p53-/-) and against the GM 07492 normal human fibroblast cell line. A SAR study revealed the importance o...