Rowell syndrome (RS) describes the rare presentation of EM like lesions found in association with a diagnosis lupus erythematosus (LE). Major diagnostic criteria includes LE, EM, and anti-nuclear antibodies. Minor chilblains, anti-Ro/anti-La antibodies, rheumatoid factor. We present 26-year-old white male seen consultation for chronic erythema multiforme (EM) duration 6 months unresponsive to t...

Background: Polycystic Ovarian Syndrome (PCOS) is common but a treatable cause of infertility in reproductive women. Thyroid hormone abnormality commonly seen Antithyroid antibodies have been detected women with PCOS. The aim the present study to evaluate antithyroid women.
 Materials and methods: A hospital based cross-sectional comparative was conducted outpatient Department Obstetrics G...

Background: Blocking the PD1-PD-L1 interaction has been shown to stimulate anti-tumour responses. Although antibody-based drugs targeting either PD-1 or PD-L1 are approved, small molecule inhibitors of currently in development. A subset these induce loss cell surface a time- and concentration-dependent manner. INCB090244 is that previously bind disrupt PD-L1/PD-1 interaction. Materials Methods:...

Neonatal tetanus (NT) is a leading cause of neonatal mortality in many parts of the world. Tetanus is a vaccine-preventable disease and is second only to measles worldwide as a cause of childhood mortality. In this study the various irnrnunoglobulin classes of anti-tetanus antibody in the sera of 105 Iranian women of childbearing age (13-45 years) were titrated by enzyme linked immunosorben...

Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic L17E trimer [FcB(L17E)3] was designed for immunoglobulin G (IgG) delivery into cells. Particle-like liquid droplets were generated by mixing Alexa Fluor 488 labeled IgG (Alexa488-IgG) FcB(L17E)3. Droplet contact the cellular membrane led to spontaneous influx and distribution of Alexa488-IgG throughout cells in seru...

Background: Infection is now the most common cause of morbidity in Systemic Lupus Erythematosus (SLE). There is lack of information regarding the specific antibody forma-tion in response to vaccines in young SLE patients. Objective: To determine the efficacy of anti-tetanus antibody response in young patients with SLE. Methods: Forty SLE pa-tients with mean age of 14.1 years (range: 7-21) and 6...

background and purpose: multiple sclerosis (ms) is believed to be an immune-mediated disorder that develops from an interaction of the individual's genetic and as yet unidentified environmental causes. the prevalence of auto-antibodies in multiple sclerosis patients and their clinical associations vary in various studies. the aim of this study was to determine serum auto antibodies in multiple ...

AIMS To establish whether PAb248 recognises human p53 as well as murine p53 and if so, to determine its distribution in normal tissues. METHODS The ability of PAb248 to recognise human p53 was established by analysis of the human osteosarcoma derived Saos-2 cell line, which lacks the p53 gene, before and after transfection with p53 cDNA, using western blotting and immunoprecipitation. Immunos...

Gaucher's disease is a rare, inherited autosomal recessive metabolic disorder due to deficiency of enzyme Glucocerebrosidase resulting in deposition glucosylceramide. Deposition glucosylceramide different organs causes dysfunction and responsible for specific systemic symptoms signs. In the present cases, first case was 24-year-old female who presented with severe weakness abdominal fullness ma...

Background: The objective of this study is to establish importance of anti-FSH antibodies in IVF outcome. Materials and Methods: This research was designed based on evaluation of several articles from 2000 till 2012 about anti-FSH antibodies in IVF outcome. Results: Serum concentrations of anti-FSH IgG and IgA were linearly associated with poorer ovarian stimulation outcome. For example 1.0 AU ...