In addition to its lipid-lowering effect, atorvastatin exerts anti-inflammatory and antioxidant effects as well. In this study, we hypothesized that atorvastatin could protect against cerebral ischemia/reperfusion injury. The middle cerebral artery ischemia/reperfusion model was established, and atorvastatin, 6.5 mg/kg, was administered by gavage. We found that, after cerebral ischemia/reperfus...

The effect of alcoholic extracts of leaf from Araucaria bidwillii Hook. [ABH] (Family: Araucariaceae) was evaluated in experimental models of pain and inflammation. Oral administration of 100, 200 and 300 mg/kg of leaf extracts of ABH were used for the above study. The leaf extract at 300 and 200 mg/kg showed significant reduction in acetic acid induced writhings in mice with a maximum effect o...

Electrical storm (ES) is defined as three or more episodes of ventricular arrhythmia requiring defibrilltaion anti tachycardia pacing within a day.Some times electrical may not respond to anti-arrhythmic drugs alone.Increased sympathetic activity plays significant role in storm.Stellate ganglion blockade reduces and helpful reduction arrhythmias. We aimed study the effectiveness outcomes percut...

r 200 001 : +972 5 ileh@na Summary Background and objective: Anti-hypertensive medications are recommended for prevention of recurrent ischemic stroke in hypertensive and normotensive patients. The objective of this study was to analyze the use of anti-hypertensive therapy in acute ischemic stroke survivors. Methods: All ischemic stroke survivors discharged from Al-watani governmental hospital ...

In Iranian traditional medicine, olive has been reported to have analgesic and anti-inflamatory effects. In the present study the anti-nociceptive and anti-inflamatory effects of olive fruit has been studied. In this study the methanolic and aqueous extract of the fruit with HER (Herbal to Extract Ratio) of 4.96% and 4.84% has been used and analgesic effect of this extract has been compared wit...

BACKGROUND AND PURPOSE Medication nonadherence is one of major risk factors for the poor outcome in ischemic stroke. Vaccination is expected to solve such a problem because of its long-lasting effects, but its effect on ischemic brain damage is still unknown. Here, we focused on vaccination for renin-angiotensin system and examined the effects of angiotensin II (Ang II) peptide vaccine in perma...

Tanshinol borneol ester (DBZ) is an experimental drug that exhibits efficacious anti-ischemic activity in rats. Although the specific metabolic properties of DBZ are still unknown, previous studies in rats have strongly suggested that DBZ is extensively metabolized after administration and thus probably acts as a prodrug. Because the enzymes involved in drug metabolism differ between humans and...

In this study, the pharmacological activity of HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphtaleneacetic acid 4-(nitrooxy)butyl ester], a nitric oxide (NO)-releasing derivative of naproxen, was compared with that of naproxen in a model of acute ischemia (40 min) and reperfusion (20 min) of the rabbit heart. HTC-3012 (3-100 microM), in spite of inhibition of 6-keto-prostaglandin F(1alpha) generati...