Some drugs that regulate estrogen are currently used as therapy for endometriosis. However, these medical treatments have significant side effects and patients who hope to become pregnant cannot overcome infertility. To compare morphological alterations and clinical symptoms, revised American Fertility Society (r-AFS) scores were compared between patients with and without leukotriene receptor a...

The aim of the study was to evaluate ovarian toxicity of tyrosine kinase inhibitor (TKI) sunitinib, since only scarce data are available on gonadal function after this treatment. Six-week-old female mice received orally, once daily, vehicle or sunitinib (50 mg/kg/d) during 5 weeks. Fertility parameters were analyzed from ovulation to litter assessment. Sunitinib exposure significantly reduced (...

The physiological role of luteinizing hormone-releasing hormone (LH-RH) in mediating the secretion of gonadotrophins is well established. However, administration of large doses of LH-RH produces a paradoxical anti-fertility effect. Thus, in women, agonists of LH-RH have been shown to inhibit ovulation (Nillius, Bergquist & Wide, 1978) and interfere with corpus luteum function (Casper & Yen, 197...

While it has long been known that female fertility is impaired by oestrogen exposure, it is unclear whether environmental pollutants with weak oestrogenic effects are sufficiently potent and prevalent to have biological effects in humans. Male fertility, or sperm concentration at least, appears to have deteriorated, and there is substantial spatial variation at both national and global level, a...

STUDY QUESTION Is it possible to restore ovarian function and natural fertility following the cryopreservation and autotransplantation of whole ovaries, complete with vascular pedicle, in adult females from a large monovulatory animal model species (i.e. sheep)? SUMMARY ANSWER Full (100%) restoration of acute ovarian function and high rates of natural fertility (pregnancy rate 64%; live birth...

Mice were passively immunized over 6 weeks with contraceptive doses of an anti-cumulus oophorus antibody preparation. The persistence of oestrus, accompanied by complete inhibition ofconception, was observed throughout treatment. After cessation of treatment, fertility was restored within 2 weeks. Histological examination did not reveal any depletion of the ovarian oocyte stock. These results w...

Tribulus terrestris is a herbal remedy which is used for various purposes in folk medicine. It has been used as tonic, aphrodisiac, astringent, analgesic, stomachic, anti-hypertensive, diuretic and urinary anti-septic. It is about 30 to 70cm high; it grows as a summer annual, has pinnately compound leaves, yellow flowers and stellate shaped carpel fruits. Since the past decades, some plants hav...