نتایج جستجو برای: anthrax vaccine
تعداد نتایج: 112646 فیلتر نتایج به سال:
We previously reported that antibodies to squalene, an experimental vaccine adjuvant, are present in persons with symptoms consistent with Gulf War Syndrome (GWS) (P. B. Asa et al., Exp. Mol. Pathol 68, 196-197, 2000). The United States Department of Defense initiated the Anthrax Vaccine Immunization Program (AVIP) in 1997 to immunize 2.4 million military personnel. Because adverse reactions in...
Bacillus anthracis is the causative agent of anthrax, a disease that affects wildlife, livestock, and humans. Protection against anthrax is primarily afforded by immunity to the B. anthracis protective antigen (PA), particularly PA domains 4 and 1. To further the development of an orally delivered human vaccine for mass vaccination against anthrax, we produced Salmonella enterica serovar Typhim...
background and objectives: bacillus anthracis is one of the most homogenous bacteria ever described. bacillus anthracis 17jb is a laboratory strain. it is broadly used as a challenge strain in guinea pigs for potency test of anthrax vaccine. material and methods: this work describes genetic characterization of b. anthracis 17 jb strain using the snps and mlva genotyping. results and conclusion:...
Nanoparticulate delivery systems for vaccine adjuvants, designed to enhance targeting of secondary lymphoid organs and activation of APCs, have shown substantial promise for enhanced immunopotentiation. We investigated the adjuvant activity of synthetic oligonucleotides containing CpG-rich motifs linked to the sucrose polymer Ficoll, forming soluble 50-nm particles (DV230-Ficoll), each containi...
BACKGROUND Bioterrorism-related anthrax exposures occurred at the US Capitol in 2001. Exposed individuals received antibiotics and anthrax vaccine adsorbed immunization. METHODS A prospective longitudinal study of 124 subjects--stratified on the basis of spore exposure, nasopharyngeal culture results, and immunization status from inside and outside an epidemiologically defined exposure zone--...
Anthrax toxin consists of protective antigen (PA) and two toxic components, lethal factor (LF) and edema factor (EF). PA binds to mammalian cellular receptors and delivers the toxic components to the cytoplasm. PA is the primary antigenic component of the current anthrax vaccine. Immunity is due to the generation of antibodies that prevent the PA-mediated internalization of LF and EF. In this s...
Anthrax, an acute to per acute infectious disease Diagnosis, treatment and control measures of all domestic animals and human beings, is caused All the blood smears examined were positive for by Bacillus anthracis and characterized by septicemia Bacillus anthracis organisms. Smears showed and sudden death with the exudation of dark tarry characteristic McFadyean reaction characterized by colore...
My friend and teacher, Fernando Flores, likes to tell his business clients the story of Pasteur and the dead cows. In the 1870s the French sheep and cattle industry was being decimated by anthrax and France’s economic position was in grave peril. At the time, the farmers were completely baffled by the mounting toll of dead cows and sheep; the cause, anthrax, had not yet been identified and name...
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