Abstract In the 19th century when arsenic was recommended treatment for psoriasis, little consideration given to toxic side-effects of potent carcinogen. Thomas Girdlestone, an English physician, is said have been first advocate use treat psoriasis. Girdlestone prescribed Fowler’s solution, a solution potassium arsenite 1%. 1876, Alexander John Balmanno Squire inadvertently discovered dithranol...

Using protein kinase C partially purified from mouse brain cytosol, we examined the effect of a number of phorbol ester and nonphorbol tumor promoters on protein kinase C enzymatic activity and [3H]phorbol 12,13-dibutyrate binding. Mezerein and phorbol 12-retinoate 13-acetate, second stage tumor promoters, as well as the weak tumor promoter 4-O-methylphorbol 12-myristate 13-acetate stimulated k...

Chemiluminescence (CL) is an index of both the generation of and reactions mediated by Cv and 'O2. The tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), is a potent stim ulator of CL by human polymorphonuclear leukocytes; treat ment with TPA (100 ng/ml) provokes a CL response that peaks within five min and persists for over 30 min. The response is proportional to concentration over th...

The effect of 20-methylcholanthrene and phorbol esters on sterol metabolism of mouse skin was studied. When 4 beta-phorbol esters were administered to mice that were previously painted once with 20-methylcholanthrene, a depression of some sterols in skin occurred, of which that of lathosterol was most marked. This effect was not observed when the order of application was reversed. Using a metab...

Expression of ErbB2 protein is inversely correlated with the prognosis in cancer patients. Consequently, strategies targeting ErbB2 remain an attractive option in treating several types of malignancies, including oral cancer. In addition, many studies have shown that emodin and emodin derivatives are able to inhibit growth of ErbB2-overexpressing tumor cells. In this study, a series of computer...

Psoriasis, which affects approximately 1-3% of the population worldwide, is a chronic inflammatory skin disorder characterized by epidermal keratinocytes hyperproliferation, abnormal differentiation, and inflammatory infiltration. Decrease in keratinocyte apoptosis is a specific pathogenic phenomenon in psoriasis. Chinese herbs have been used for the treatment of psoriasis in China showing prom...

The treatment of psoriasis vulgaris in the first half of the 20th century revolved on the intake of arsenical preparations and undecylenic acid and the topical use of mainly keratolytics, chrysarobin, tar regimens, and dithranol formulations. In 1951 a major event leading to a dramatic change occurred when a 36-year-old man known only by the initials L.R. had a remission at New York’s Kings Cou...

Several topical treatments such as ointments, keratolytics, dithranol, tar, corticosteroids and Vitamin D3 analogues are commonly used in the treatment of mild and/or moderate psoriasis. These treatments can be associated with a variety of local and systemic side effects, as well as to very often unsatisfactory results. The purpose of this critical review of the literature is to evaluate the ef...

Aim of the study : To compare the efficacy and tolerability of various topical therapies like short contact Lipsomal dithranol ointment, 0.1% Betamethasone valerate ointment and liquid paraffin for psoriasis. Materials and Methods: This study was conducted in dermatology department of a tertiary hospital and a total of sixty patients who attended the Psoriasis clinic were randomly allocated to ...

BACKGROUND Hair is susceptible to exogenous sources of discoloration. There are several exogenous etiologies for yellow hair discoloration, including tobacco. PURPOSE We describe the clinical features of five men with tobacco-associated yellow discoloration of their mustache, a condition known as "smoker's mustache." We also review the characteristics of men with tobacco-associated yellow dis...