Four amidine NR2B-selective NMDA receptor antagonists, N-( 2-methoxy benzyl) -3-phenyl-acrylamidine, N-[diduterio(2-methoxyphenyl) methyl]-3-phenyl-acrylamidine, N-benzyl-3-phenyl-acryl amidine and N-[diduterio(phenyl)methyl]-3-phenyl-acrylamidine, all fourlabeled with carbon-14 in the 1-position, have been synthesized as part of 5-step sequence fromBa14CO3.

Although calcium antagonists are used as a first-line antihypertensive agent, controversy attends the renal microvascular effects of calcium antagonists. Since calcium antagonists elicit predominant vasodilation of the afferent arteriole, they might ostensibly aggravate glomerular hypertension. Recently, novel types of calcium antagonists have been developed, some of which are reported to dilat...

administration of apomorphine and amphetamine induces climbing behavior in mice due to stimulation of brain dopamine receptors. in the present study, the effects of adrenoceptor agonists and antagonists on amphetamine-induced climbing have been investigated. intraperitoneal (i.p.) injection of different doses of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p

The pathogenesis of essential hypertension, congestive heart failure, and reno-vascular hypertension is related to angiotensin II. This study presents QSAR modeling for a set compounds acting as II receptor antagonists based on the Monte Carlo optimization with molecular graph-based SMILES notation descriptors. Conformation independent models were developed three random splits. Various statisti...

Background: The prostate gland is surrounded by periprostatic adipose tissue (PPAT) that can release mediators interfere in function. In this study, we examined the effect of supernatant obtained from obese mice on reactivity vitro and viability human prostatic epithelial cell lines. Methods: Male C57BL/6 were fed a standard or high-fat diet after which PPAT was isolated, incubated Krebs-Hensel...