The pero1 and the pers mutations in Drosophila melanogaster, which seem to eliminate or speed up, respectively, the clocks underlying biological rhythmicity, were mapped to single nucleotides. Chimeric DNA fragments consisting of well-defined wild-type plus mutant DNA subsegments were constructed, introduced into flies by germ-line transformation, and assayed for biological activity. These expe...

The effect of dietary persimmon (Pers, 7.0%) on lipid metabolism and antioxidant activity was investigated in 40 male Wistar rats adapted to cholesterol-free or 1% cholesterol diets. The rats were divided in four groups of 10. The basal diet contained wheat starch, casein, soybean oil, and mineral and vitamin mixtures. The control group (C) consumed the basal diet. To the basal diet were added ...

Penelitian ini bertujuan untuk mengkaji syarat pendirian media online dan proses penyelesaian sengketa pers di Dewan Pers. Metode yang digunakan dalam penelitian adalah metode normatif dengan melakukan analisis terhadap undang-undang peraturan terkait serta studi pustaka topik dibahas. Hasil menunjukkan bahwa melalui jalur ditentukan oleh Undang-Undang Nomor 40 Tahun 1999 Tentang Pers Peraturan...

Phase resetting by light is an important feature of circadian rhythms, and the current Drosophila model focuses on light-mediated degradation of the clock protein TIMELESS (TIM). PERIOD (PER) is the binding partner of TIM and a major repressor of the molecular clock, but direct evidence of PER in phase resetting is lacking. Because light sensitivity of the per(S) short period mutant strain is s...

Hunt showed that the notion of PER-based strictness properties subsumed the incomparable notions of idealand projection-based properties on non-lifted value spaces. We extend Hunt’s idea so it can encompass other comportment properties (such as totality) by separating the information and fixpoint orderings. We then define a class of uniform PERs (in the sense that they treat non-bottom ground e...

Question: Annona muricata Linn. contains a group of bioactive long chain fatty acid derivatives called Annonaceous acetogenins, which have shown selective cytotoxicity against several cancer cell lines and other abnormal cells by a known mechanism. The current study analyzed the phytochemical and antioxidant properties of the fruit skin ethanolic extract of Annona muricata (ESA) and its effect ...

BACKGROUND Young relatives of individuals with schizophrenia (i.e. youth at familial high-risk, FHR) are at increased risk of developing psychotic disorders, and show higher rates of psychiatric symptoms, cognitive and neurobiological abnormalities than non-relatives. It is not known whether overall exposure to environmental risk factors increases risk of conversion to psychosis in FHR subjects...

Light is the dominant environmental cue that provides temporal information to circadian pacemakers. In Drosophila melanogaster some period gene mutants have altered free-running circadian periods but entrain to 24 h light-dark cycles. To address the mechanism of light entrainment in Drosophila, we examined the effects of constant light on the period gene (per) and timeless gene (tim) products i...