Histocompatibility typing was carried out in 74 patients with psoriasis and an inflammatory arthropathy. In 40 patients with peripheral arthropathy characterized by distal interphalangeal joint involvement, 13 (32-5%) were HLA-B27 positive, significantly higher than the control frequency (P = 5-8 X 10 (-6). 26 of the 40 patients did not have ankylosing spondylitis or radiological sacroiliitis a...

Anti-tumor necrosis factor agents are effective drugs for inflammatory diseases such as rheumatoid arthritis and bowel disease. Although it is indicated the treatment of Ankylosing Spondylitis, there recent publications about paradoxical side effects due to these agents, mostly in form case reports. In this article, we present psoriasis that develops paradoxically a patient with ankylosing spon...

PURPOSE The risk of atherosclerosis is increased in several rheumatological disorders, but any such risk remains unproven for ankylosing spondylitis. Since carotid intima-media thickness is an indicator of early atherosclerosis, and the paraoxonase (PON1) enzyme has antioxidant activity to prevent LDL oxidation, we aimed to identify: 1) the relationship between carotid intima-media thickness (C...

We investigated the distribution of human leukocyte antigen (HLA)-B27 subtypes in Uygur ankylosing spondylitis patients in Xinjiang. B27-positive patients with ankylosing spondylitis were subtyped by using polymerase chain reaction-sequence-based typing. The HLA-B27 subtype frequencies of Uygur patients were compared with those in Han patients in Xinjiang and the other areas of China. B*2705 wa...

OBJECTIVE Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene. Because candidate genes responsible for susceptibility to ankylosing spondylitis are mostly unknown and available data suggest that there may be problems related to the nitric oxide pathway, such as endothelial dysfunction ...

Aims: The objective of the present study was to investigate the parameters related to disease activity in patients with Ankylosing Spondylitis (AS). Materials and methods: Fifty-three patients with AS who fulfilled the modified New York criteria were included in this study. The demographic data of the patients were recorded. Laboratory evaluation of the patients comprised erythrocyte sedimentat...

The pathogenesis of the cauda equina syndrome of ankylosing spondylitis is unknown. The long duration between the onset of ankylosing spondylitis and neurological symptoms (average 35 years in the Mayo Clinic series') argues against a shared inflammatory cause, as does the relative normality of CSF.' 2 Matthews suggested that arterial pulsations transmitted to the CSF might produce not only the...

Xenon-133 was used to study regional pulmonary function in nine patients with chest cage rigidity due to ankylosing spondylitis. In comparison with normal subjects, the patients showed an overall diminution in lung volume and the proportion of inhaled xenon reaching the lung apices was reduced but the distribution of injected xenon was normal. The possible relationship between these findings an...

After precipitation of the HLA-B27 antigen from the surface of peripheral blood lymphocytes (PBL) by means of an anti-HLA-B27 allospecific monoclonal antibody 2-dimensional gel electrophoresis was used to compare the structure of the B27 antigens derived from 5 patients with ankylosing spondylitis with that of healthy HLA-B27 positive counterparts. No significant difference in polypeptide struc...