Flowability - as measured by hopper discharge rate, angle of repose and Carr's index (CI) - of surface modified microcrystalline cellulose granules was investigated experimentally. Three-dimensional simulations of the granule flow were performed, using the discrete element method (DEM), including either sliding and rolling friction or sliding friction and cohesion in the model. Granule surface ...

Bone is a fabric of organic material reinforced and stiffened by hydroxyapatite mineral crystals attached and interdigitated with proteins.1 When mineralized regions grow large enough, however, they could interfere with each other, conceivably in a manner analogous to rocks in a bag. At the 53rd Meeting of the Orthopaedic Research Society, a presentation by K. Tai, working with F. Ulm and Chris...

The study aimed to determine the biotechnical characteristics (physical properties, color characteristics, angle of repose, and coefficient friction) seeds safflower cultivars. Moisture contents Asal, Balcı, Dinçer cultivars were determined as 8.64%, 9.52%, 8.57%, respectively. width (4.04 mm) cultivar gave higher values than other Statistically significant (p

The aim of present study were to arrest the problem of content uniformity without the use of harmful organic solvent and to improve ex vivo permeability of captopril, a low dose class III drug as per biological classification system. Eutectic mixture of camphor and menthol was innovatively used in the work. Captopril solution in eutectic mixture was blended with Avicel PH 102 and then the mixtu...

In the present study, novel co-processed superdisintegrants were developed by solvent evaporation method using crospovidone and sodium starch glycolate in different ratios (1:1, 1:2 & 1:3) for use in the fast dissolving tablet formulations. The developed excipients were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. The...

– The flow of granular matter such as sand is often characterized by the motion of a thin superficial layer near the free surface, while the bulk of the solid remains immobile. A pair of equations called the BCRE equations (Bouchaud J-P., Cates M. E., Ravi Prakash J. and Edwards S. F. J. Phys. 4 (1994) 1383) have been proposed to model these flows and account for the dynamic exchange of mass be...