Acromegaly is a slowly progressing condition resulting from excess growth hormone (GH), generally caused by a GH-secreting pituitary adenoma. Cancer is the third most common cause of mortality in patients with acromegaly, and insulin-like growth factor 1 (IGF-1) is known to influence tumor formation by increasing cell proliferation and inhibiting apoptosis. Multiple myeloma (MM) is a plasma cel...

Pituitary adenoma is a rare neoplasm in childhood, with prolactin and adrenocorticotropic hormone (ACTH)-secreting adenomas predominating in this age group. Herein is reported a case of an ACTH-producing macroadenoma with an unusual histology that occurred in a 2-year-old girl. Because of the patient's age and the macroadenoma's suprasellar location and large size (up to 4 cm in diameter), radi...

Choricarcinoma is a beta human chorionic gonadotrophin secreting neoplasm pertinent to uterus and pregnancy mostly. It occurs primarily in gonads but rarely in extragonadal sites. Primary hepatic choriocarcinoma is an extremely rare tumor. Most of the reported cases are seen in infants representing metastasis from an occult placental choriocarcinoma. Till date, only 7 cases of primary hepatic c...

Different types of benign or malignant cystic lesions can be observed in the pancreas. Pancreatic cystic lesions are classified under pathology terms into simple retention cysts, pseudocysts and cystic neoplasms. Mucinous cystic neoplasm is a frequent type of cystic neoplasm and has a malignant potential. Serous cystadenoma follows in frequency and is usually benign. Intraductal papillary mucin...

Abstract Multiple Myeloma (MM) is a neoplastic clonal proliferation of terminally differentiated B- lymphocytes. It accounts for 1.6% all cancers and about 10-15% hematological malignancies in the United States. Monoclonal immunoglobulins provide an indication tumor burden patients with plasma cell neoplasm. Recent development has shown that proportion intact immunoglobulin producing multiple m...

hyperandrogenism affects 2-6% of all women. hypertension is one of disturbances which is related to androgen excess. higher intakes of vitamin c and vitamin e have been associated with lower blood pressure. tho investigate the effect of these vitamin supplementation on blood pressure in hyperandrogenic women, a randomized, double-blind, placebo-controlled study was designed on 56 women 18-54 ye...

Multiple myeloma is a malignant neoplasm of plasma cells characterized by proliferation of a single clone of abnormal immunoglobulin-secreting plasma cells. Since the amount of hemopoietic bone marrow is decreased in the maxilla, oral manifestations of multiple myeloma are less common in the maxilla than in the mandible. We report the case of 33-year-old Japanese man who presented with a mass i...

The murine myeloma MOPC-315 secretes a paraprotein which binds dinitrophenylated compounds. Maturational sub sets which mimic normal B-cell differentiation were shown to exist within this monoclonal neoplasm. The maturational sub sets were defined by an in vivo stem cell activity (plasmacytoma colony-forming unit-spleen), DMA synthesis ([3H]thymidine in corporation), membrane-bound paraprotein,...

a set of one hundred and twenty nine patients with known primary malignancy and suspected brain metastasis was reviewed in present study. the patients were selected among patients presented to the mri section of imam khomeini hospital or a private mri center in tabriz (iran). primary tumor site, clinical manifestations, number and site of lesions were identified in this patient population. the ...