Chronic lymphocytic leukaemia (CLL) is the most common B-cell malignancy in the western world and exists as subtypes with very different clinical courses. Myeloid cell leukemia 1 (Mcl-1) is one member of Bcl-2 family proteins that has been shown to be expressed in various tissues and malignant cells, including CLL, where its expression is significantly associated with a failure to achieve compl...

Background Down syndrome is the most common chromosomal anomaly. Dysmorphic features can occur in several organs in this syndrome. Cardiac anomalies with a prevalence of 50% are the most common anomalies responsible for death during the first two years of life. We aimed to determine the prevalence of cardiac anomalies among Down syndrome patients admitted to two tertiary hospitals in Kermanshah...

Objectives:  This  study  aimed  to  examine  the  effectiveness  of  life  skills  training  on  quality  of  life  in mothers of children with Down syndrome.  Methods:  This  research  was  done  as  a  semi-experimental  with  pre-post  test &nbs...

conclusions parents were blood relatives in 33 (33%) of the patient cases, which is a very high rate. therefore, non-random mating is an important issue in developing countries that needs more attention results 100 patients with down syndrome and congenital heart disease were evaluated; 52 were female (52%) and 48 were male (48%). the average birth weight of the subjects was 2745 ± 523 (mean ± ...

These experiments examined the effects of pre-test intra dorsal hippocampus (intra-CA1) administration of GABAA receptor agonist and antagonist, muscimol and bicuculline respectively, on state-dependent learning induced by lithium. Male NMRI mice were trained in a one-trial step-down inhibitory avoidance task, and immediately after training they received IP injections of either saline (10 mL/kg...