CONTEXT Tumor induced osteomalacia related to anaplastic thyroid cancer has never been reported. OBJECTIVE We describe a case of tumor induced osteomalacia (TIO) in a patient with a fibroblast growth factor 23 (FGF-23) secreting anaplastic thyroid carcinoma. The current imaging modalities are reviewed. DESIGN AND INTERVENTION Clinical, biochemical, and radiological assessments were done, in...

The clinical significance of anaplastic features, a rare event in pilocytic astrocytoma (PA), is not fully established. We reviewed 34 PA with anaplastic features (Male = 21, Female = 13; median age 35 y, 5 to 75) among approximately 2200 PA cases (1.7%). Tumors were included which demonstrated brisk mitotic activity [at least 4 mitoses/10 high power fields (400 x )], in addition to hypercellul...

Malignant gliomas consist of glioblastomas, anaplastic astrocytomas, anaplastic oligodendrogliomas and anaplastic oligoastrocytomas, and some less common tumors such as anaplastic ependymomas and anaplastic gangliogliomas. Malignant gliomas have high morbidity and mortality. Even with optimal treatment, median survival is only 12-15 months for glioblastomas and 2-5 years for anaplastic gliomas....

BACKGROUND Anaplastic thyroid cancer is considered to be one of the most aggressive human malignancies, and the mean survival time after diagnosis is approximately six months, regardless of treatments. This study aimed to examine how EpCAM and its related molecules are involved in the characteristics of anaplastic thyroid carcinoma. METHODOLOGY/PRINCIPAL FINDINGS Two differentiated thyroid ca...

Anaplastic large cell lymphoma (ALCL) is a histological subtype of non-Hodgkin lymphoma, largely characterized by anaplastic kinase (ALK) positivity, resulting from the chromosomal translocation t(2;5). We report pediatric case ALK-positive ALCL with primary concomitant involvement bone and central nervous system (CNS); thereafter, literature review about CNS was conducted. According to analyze...

Most primary CNS tumors are astrocytic tumors. Glial classified according to histological criteria. The WHO classification for malignant gliomas in adults includes grades II through IV. Terms that classify grade astrocytomas (A), oligodendrogliomas (ODG), or mixed (GM). Grade III named similarly, and preceded by the word anaplastic, example, anaplastic astrocytoma (AA), oligodendroglioma (ODGA)...

A thyroidectomy was performed for a rapidly enlarging neck mass in woman her 70s. The tumor diagnosed by pathology as an anaplastic thyroid carcinoma. Which of the following statements regarding carcinoma is most accurate?a.Anaplastic highly aggressive malignancy that usually occurs persons their second to third decade life.b.Almost all carcinomas occur setting previous radiation neck.c.Anaplas...

Anaplastic thyroid cancer (ATC) is the rarest (1–2%) form of cancer, but also most aggressive and associated with worst prognosis. The survival median rate 5–6 months, whereas only 20% patients survive more than one year from diagnosis, even though usage radiotherapy surgical resection. growing incidence ATC determine need for new prophylactic, diagnostic therapeutic solutions. Metformin was fi...

Since it is usually accepted that the more anaplastic bronchial carcinomas have a worse outlook, it might be thought that the type of cell found in a positive biopsy from bronchoscopy would give a clear lead as to prognosis. Indeed, Nicholson, Fox, and Bryce (1957) stated that the prognosis was best for squamous-celled growths and almost hopeless for spheroidal-celled, oatcelled, and anaplastic...