Clinical observations with AN-1792 using tissue amyloid plaque immunoreactivity (TAPIR) analyses established for the first time evidence in humans that antibodies against beta-amyloid-related epitopes are capable of slowing progression in Alzheimer's disease. Antibodies derived upon TAPIR assay selection may specifically target the pathologic neoepitopes of aggregated A beta species present in ...

In this document, we define the NADA security architecture based on refined use case scenarios, a derived high level model and security analysis. For the architecure design and verification we are applying the well known STRIDE model.

Spinning dust appears to be the best explanation for the anomalous emission that has been observed at ∼ 10 − 60 GHz. One of the best examples of spinning dust comes from a HII region in the Perseus molecular cloud. Observations of other HII regions also show tentative evidence for excess emission at frequencies ∼ 30 GHz, although at lower emissivity levels. A new detection of excess emission at...

In this paper, we introduce the concept of 3-D radar signatures in a slow time-range-Doppler, fast timerange-Doppler and frequency-range-Doppler. Then, we describe how to utilize 3-D time or frequency-rangeDoppler signatures to extract information for detecting, relocating and re-focusing moving targets. Finally, we use AN/APY-6 X-band radar data for the demonstration of ground moving target de...

In a multi-study naturalistic quasi-experiment involving 269 students in a semester-long introductory philosophy course, we investigated the effect of teaching argument diagramming (AD) on students’ scores on argument analysis tasks. An argument diagram is a visual representation of the content and structure of an argument. In each study, all of the students completed preand posttests containin...

Introduction: Consumption of anabolic steroids causes damage to various tissues, including the heart. The aim of this study was to investigate the effect of resistance training (RT) on malondialdehyde (MDA) and protein carbonyl (PC) in the heart tissue of rats exposed to stanozolol (S). Methods: In this experimental study, 18 rats with mean age of 8 weeks and weight range of 150 to 200 g were ...

The aim of this study was to investigate the effect of treatment of experimental ovarian cancers with targeted cytotoxic analogs as single compounds and in combination. Targeted cytotoxic analogs of bombesin (AN-215), somatostatin (AN-238), and luteinizing hormone-releasing hormone (AN-207) consisted of 2-pyrrolinodoxorubicin (AN-201) linked to the respective peptide carrier. AN-238 at 200 nmol...

Background: To evaluate impact of spironolactone (S) on pulmonary toxicity of concomitant use of thoracic radiotherapy (RT) and trastuzumab (T).  Materials and Methods: Eighty rats were divided into eight groups: group (G) 1 was control group; G2, G3 and G4 were RT, S and T groups; G5, G6, G7 and G8 were RT+T, T+S, RT+S and RT+T+S groups respectively. Rats were sacrificed at 6 hour, 21 and 100 ...

In searching for macromolecular antitumor antibiotics of microbial origin, 2,875 kinds of Actinomycetes culture fluids were applied to a newly developed test system which consisted of antimicrobial assay using a macromolecule permeable mutant, DNA damage assay and mutagenicity test. As a result, 78 macromolecular antibiotics were found. Among them, 15 antibiotics precipitable with ammonium sulf...