We explore phenomenologies of the topflavour model for the LEP experiment at m Z scale and the atomic parity violation (APV) experiment in the Cs atoms at low energies. Implications of the model on the Z peak data are studied in terms of the precision variables ǫ i 's. We find that the LEP data give more stringent constraints on the model parameters than the APV data.

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Retroviral protease inhibitors (PIs) are fundamental pillars in the treatment of HIV infection and acquired immunodeficiency syndrome (AIDS). Currently used PIs are designed against HIV-1, and their effect on HIV-2 is understudied. Using a modular HIV-2 protease cassette system, inhibition profiling assays were carried out for protease inhibitors both in enzymatic and cell culture assays. Moreo...

There are a number of new developments in the fight against the HIV epidemic. New drugs are being developed, results are being reported from a number of clinical trials, and there are some new strategies in disease management. Currently, there are eleven approved medications for HIV. Several new drugs or studies are highlighted: adefovir dipivoxil (preveon), which is now available under an expa...

Novel antiretroviral drugs include protease (PR) inhibitors (e.g. atazanavir, tipranavir and darunavir) that block HIV-1 maturation and show remarkable antiviral potency on drug-resistant isolates. However, the strains used as prototypes in the design of the novel drugs belong to a specific clade (i.e. HIV-1 group M subtype B), which is the most prevalent in developed countries. At the same tim...

The scope of this work was to investigate the migration behavior of the currently used protease inhibitors for antiretroviral therapy of people infected with the human immunodeficiency virus and to develop a method for their capillary electrophoretic separation and determination. All of the protease inhibitors (indinavir, saquinavir, nelfinavir, amprenavir, and ritonavir) contain at least one b...

We report the most precise measurement to date of a parity-violating asymmetry in elastic electron-proton scattering. The measurement was carried out with a beam energy of 3.03 GeV and a scattering angle 〈θlab〉 = 6.0 ◦, with the result APV = (−1.14 ± 0.24 (stat) ± 0.06 (syst)) × 10. From this we extract, at Q = 0.099GeV, the strange form factor combination GsE + 0.080G s M = 0.030 ± 0.025 (stat...

We show that the two scenarios able to explain the Hera anomaly — a new leptoquark coupling or a new contact interaction — predict new contributions to atomic parity violation. These corrections are sufficiently large and different that a feasible reduction in the dominant atomic theory uncertainty could give some hint in favour of one of the two scenarios. 1 The excess of events at large Q obs...