Prostate cancer is one of the male killing diseases and early detection of prostate cancer is the key for better treatment and lower cost. However, the number of prostate cancer cells is low at the early stage, so it is very challenging to detect. In this study, we successfully designed and developed upconversion immune-nanohybrids (UINBs) with sustainable stability in a physiological environme...

ENGINEERING NANOPARTICLE AND NANORING PATTERNS FOR THESTUDY OF MOLECULAR CRYSTALLIZATION UNDER NANOCONFINEMENTbySUNXI WANGAugust 2013Advisor: Dr. Guangzhao MaoMajor: Chemical EngineeringDegree: Doctor of PhilosophyThis dissertation focuses on generating the inorganic nanoparticle/organicnanorod hybrid nanostructures by the strategy of nanoparticle induced...

The integration of silver and gold nanoparticles with graphene is frequently sought for the realization of hybrid materials with superior optical, photoelectric and photocatalytic performances. A crucial aspect for these applications is how the surface plasmon resonance of metal nanoparticles is modified after assembly with graphene. Here, we used the discrete dipole approximation method to stu...

Comb-shaped amphiphilic polymers are rapidly emerging as an alternative approach to amphiphilic block copolymers for hydrophobic drug solubilization. These polymers consist of a homopolymer or copolymer backbone to which hydrophobic and hydrophilic pendant groups can be grafted resulting in a comb-like architecture. The hydrophobic pendants may consist of homopolymers, copolymers and other low-...

We demonstrated here a facile and efficient synthesis of polyhedral oligomeric silsesquioxane-based amphiphilic polymer by thiol-ene click chemistry. The properties of polyhedral oligomeric silsesquioxane (POSS)–PEG amphiphilic polymers were studied in detail by a combination of 1H NMR, 13C NMR, 29Si NMR FT-IR, GPC, and TG analysis. The newly-designed thiol-ene protocol obtains only anti-Markov...

We present a stochastic rotation dynamics model of amphiphilic molecules. Vesicle formation of amphiphilic molecules in a thermal fluctuating fluid is demonstrated in this paper. In the model, the interaction of amphiphilic molecules is represented by Lennard–Jones potentials, and stochastic rotation dynamics [T. Ihle, D.M. Kroll, Stochastic rotation dynamics: A Galilean-invariant mesoscopic mo...

Myoglobin is one of the most commonly used cardiac biomarkers for the clinical diagnosis of acute myocardial infarction, which is the leading cause of mortality worldwide. Herein, we report a novel ‘signal-on’ electrochemical immunosensing system for the quantitative detection of myoglobin without the need for natural enzymes and additional electron mediators. The assay was readily carried out ...

The over expression of thioredoxin domain-containing protein 5 (TXNDC5) can promote the growth of castration-resistant prostate cancer (CRPC). A novel highly sensitive photoelectrochemical (PEC) aptsensor was developed for the detection of TXNDC5 by using the nanohybrids (TiO2 NRs/NCQDs) of nitrogen-doped carbon quantum dots (NCQDs) and TiO2 nanorods as the photo-to-electron conversion medium. ...

Nanozymes have been widely developed as supplements of natural enzymes owing to their relatively low cost, high mass production, easy storage, good stability, and reusability. By controlling the particle size, nanozymes’ catalytic activities can distinctly be improved. The porous materials such covalent organic frameworks (COFs) are definitely considered promising supports for in situ preparati...

Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydropho bic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures Such as micelles and poly mersomes. With suitable metals present in th...