We describe the first species-specific detection of bacterial pathogens in human clinical fluid samples using a microfabricated electrochemical sensor array. Each of the 16 sensors in the array consisted of three single-layer gold electrodes-working, reference, and auxiliary. Each of the working electrodes contained one representative from a library of capture probes, each specific for a clinic...

Presented is a single-ended potentiostat topology with a new interface connection between sensor electrodes and potentiostat circuit to avoid deviation of cell voltage and linearly convert the cell current into voltage signal. Additionally, due to the increased harmonic distortion quantity when detecting low-level sensor current, the performance of potentiostat linearity which causes the detect...

This study details the use of printing and other additive processes to fabricate a novel amperometric glucose sensor. The sensor was fabricated using a Au coated 12.7 μm thick polyimide substrate as a starting material, where micro-contact printing, electrochemical plating, chloridization, electrohydrodynamic jet (e-jet) printing, and spin coating were used to pattern, deposit, chloridize, prin...

The use of tris (2,2?-bipyridil) copper (II) chloride complex, [Cu(bipy)3]Cl2 /6H2O, as a biomimetic catalyst, is reported in the construction of an amperometric sensor for dopamine. The sensor was prepared modifying a glassy carbon electrode with a Nafion† membrane doped with the complex. The optimized conditions for the sensor response were obtained in 0.25 mol dm 3 Pipes buffer (pH 7.0) cont...

A soft contact-lens amperometric glucose sensor as novel wearable device of body sensor network was fabricated and tested. Also, the sensor was utilized to tear glucose monitoring. The sensor was constructed by immobilizing GOD onto a flexible oxygen electrode, which was fabricated using “Soft-MEMS” techniques onto a functional polymer membrane. In purpose of bioinstrumentation, adhesive agents...

Novel DNA-sensor with enzymatic amplification of the signal has been developed on the base of glassy carbon electrode modified with ds-DNA and horseradish peroxidase (HRP). Phenothiazine dyes Methylene Blue and Methylene Green were used as electrochemical markers for the detection of sulfonamide and anthracycline preparations able to interact with DNA. The biosensor signal related to HRP oxidat...

An amperometric method was developed by using a lead working electrode in acetonitrile organic solution for detecting acetic acid. The mechanisms of electrochemical reaction were corresponding to the reduction of acetic ions in acetonitrile organic solution. The steady state amperometric current resulted from the reduction of acetic ions to produce the aldehyde in a two-electron process. In the...

In this work, we investigate the possibility of using double cobaltite with composition PrBaCo2O6 as an electrocatalyst in oxidation organic compounds. A screen-printed carbon electrode modified drop method was investigated a sensor for glucose. The amperometric signal is logarithmically dependent on analyte concentration according to equation: I (μA) = 9.485⋅ln(C (mM)) + 17.864 (R 0.9951). lim...

In the present study, we monitored the alkaline phosphatase (ALP) activity of embryoid bodies (EBs) of mouse embryonic stem (ES) cells using a large-scale integration (LSI)-based amperometric device with 400 sensors and a pitch of 250 μm. In addition, a simulation analysis was performed to reveal the positional relationship between the EBs and the sensor electrodes toward more precise measureme...

A new electron-transfer mediator, 5-[2,5-di (thiophen-2-yl)-1H-pyrrol-1-yl]-1,10-phenanthroline iron(III) chloride (FePhenTPy) oriented to the nicotinamide adenine dinucleotide-dependent-glucose dehydrogenase (NAD-GDH) system was synthesized through a Paal-Knorr condensation reaction. The structure of the mediator was confirmed by Fourier-transform infrared spectroscopy, proton and carbon nucle...