In this thesis we develop a wrapper for scientific data stored in ROOT files using Amos II, a functional DBMS. ROOT is an object-oriented framework for representing high-energy physics data. We investigate possible ways to represent ROOT C++ objects in a functional data model and propose a simple and fast mapping method. We define a schema to represent ROOT object storage containers, objects an...

MicroRNA (miRNA)-guided argonaute (Ago) controls gene expression upon binding to the 3' UTR of mRNA. The miRNA function can be competitively inhibited by single-stranded anti-miRNA oligonucleotides (AMOs). In this study, we constructed a novel type of AMO flanked by interstrand cross-linked 2'-O-methylated RNA duplexes (CLs) that confer a stable helical conformation. Compared with other structu...

In their book Rapoport and Zink constructed rigid analytic period spaces F for Fontaine’s filtered isocrystals and period morphisms from moduli spaces of p-divisible groups to some of these period spaces. They conjectured the existence of an étale bijective morphism F → F of rigid analytic spaces and of interesting local systems of Qp-vector spaces on F. For those period spaces possessing perio...

FORENOTE (2007): The remarkable conjecture of Langlands and Rapoport (1987) gives a purely group-theoretic description of the points on a Shimura variety modulo a prime of good reduction. In an article in the proceedings of the 1991 Motives conference (Milne 1994, §4), I gave a heuristic derivation of the conjecture assuming a sufficiently good theory of motives in mixed characteristic. I wrote...

A specific phosphatase for 2,3-diphosphoglyceric acid (2,3DPGA’) has been reported by Rapoport and .Luebering (1) and by Sutherland et al. (2). Rapoport and Luebering (1) studied in some detail a number of the kinetic properties of glycerate2,3+liphosphatase from rat and rabbit skeletal muscle. Wide distribution of this phosphatase in animal tissues has been noted. While in this laboratory, Dr....

Lepage, G. A. & Umbreit, W. W. (1943). J. biol. Chem. 147, 263. Lepage, G. A. & Umbreit, W. W. (1945). In Manometric Technique8 and Related Method7 for the Study of Tissue Metabolism, by W. W. Umbreit, R. H. Burris & J. F. Stauffer. Minneapolis: Burgess Publishing Co. Leva, E. & Rapoport, S. (1943). J. biol. Chem. 149,47. Popjak, G. & Muir, H. (1949). Biochem. J. 45, xi. Rapoport, S., Leva, E. ...