BACKGROUND This study was conducted in a private clinic to report frequency, presentation and management of malaria in children presenting with fever. METHODS 160 Children of age varying from 42 days to 15 years were included in this study, during a period of 1999-2004. RESULTS AND CONCLUSIONS Malaria was confirmed in 154 cases, including 114 male and 46 female children. In 6 cases malarial...

There are wide variations in the threshold used to define in vitro resistance of Plasmodium falciparum to amodiaquine (AQ), probably due to differences in methodology and interpretation. In vitro susceptibility data of Colombian P. falciparum strains to AQ and N-desethylamodiaquine is used to illustrate the need to standardized methodologies and compare inhibitory concentrations, instead of res...

Abstract Background The national policy for malaria treatment of the Democratic Republic Congo recommends two first-line artemisinin-based combinations uncomplicated malaria: artesunate-amodiaquine and artemether-lumefantrine. This study investigated presence markers associated with resistance to current combination therapy (ACT) in isolates Plasmodium falciparum from failure patients Congo. Me...

José Pedro Gil1,2,3 1Department of Physiology and Pharmacology, Drug Resistance Unit, Division of Pharmacogenetics, Karolinska Institutet, Stockholm, 2Department of Biomedical Sciences, University of Algarve IBB-Institute for Biotechnology and Bioengineering, The Centre for Molecular and Structural Biomedicine, Gambelas, 3Department of Biological Sciences, The Harpur College of Arts and Science...

BACKGROUND Artemisinin-combination therapy (ACT) is recommended as first-line treatment of falciparum malaria throughout the world, and fixed-dose combinations are preferred by WHO; whether a single gametocytocidal dose of primaquine should be added is unknown. We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the a...

The objective of this study was to monitor the effectiveness of artesunate-amodiaquine fixed-dose combination tablets (ASAQ Winthrop®) in the treatment of uncomplicated Plasmodium falciparum malaria in Côte d'Ivoire. Two enrolment periods (November 2009 to May 2010 and March to October 2013) were compared using an identical design. Subjects with proven monospecific P. falciparum infection accor...

Abstract Background Evidence of Plasmodium resistance to some the current anti-malarial agents makes it imperative search for newer and effective drugs combat malaria. Therefore, this study evaluated whether co-administrations xylopic acid-amodiaquine acid-artesunate combinations will produce a synergistic effect. Methods Antiplasmodial effect acid (XA: 3, 10, 30, 100, 150 mg kg ?1 ), artesunat...

The 50% inhibitory concentration (IC50s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No correlation or weak correlations in the responses to benflumetol and pyrimethamine, chloroquine, amo...