Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th) subsets including Th22, Th17, and Th1 cells play a pivotal role. However, the role of T helper (Th) subsets in the immune pathogenesis of AML remains unclear. Here, we investigated frequencies of Th22, Th17, pure Th17, and Th1 cells in the peripheral blood (PB) of AML patients. We demonstrated that Th22, Th17,...

To obtain background information on elderly acute myeloid leukemia (AML), unselected data covering 159 patients aged 60 years or over with AML from 14 hospitals in Nagoya, Japan was analyzed retrospectively. Among these patients, 119 had de novo acute AML, 32 had AML which evolved from myelodysplastic syndrome (MDS-AML), and 8 had other types of leukemia. The survey showed that MDS-AML tended t...

Acute myeloid leukemia (AML) is a heterogeneous group of aggressive bone marrow cancers arising from transformed hematopoietic stem and progenitor cells (HSPC). Therapy-related AML and MDS (t-AML/MDS) comprise a subset of AML cases occurring after exposure to alkylating chemotherapy and/or radiation and are associated with a very poor prognosis. Less is known about the pathogenesis and disease-...

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) play a fundamental role in the BM microenvironment (BME) and abnormalities of these cells may contribute to acute myeloid leukemia (AML) pathogenesis. The aim of the study was to characterize the cytokine and gene expression profile, immunophenotype and cytogenetics of BM-MSCs from AML patients compared to normal BM-MSCs from healthy donor...

specified (AML-NOS), AML with myelodysplasia-related changes (AML-MRC), multilineage dysplasia (MLD). Abstract The WHO classification of acute myeloid leukemia (AML) is hierarchically structured and integrates genetics, data on patients' history, and multilineage dysplasia (MLD). The

Blacks respond to therapy with amlodipine (AML) and hydrochlorothiazide (HCZ) with greater diuresis and natriuresis than whites, a situation that may lead to prerenal azotaemia and other problems. Although AML and HCZ are frequently used as antihypertensive agents in Nigeria, the effects of the combination treatment on renal function has been poorly examined. Therefore, to evaluate the effects ...

Acute myeloid leukemia colony forming cells (AML-CFU) require the addition of colony stimulating factors (CSFs) for in vitro proliferation. Recently, we isolated a human recombinant multilineage CSF (hMulti-CSF). We investigated the ability of hMulti-CSF to stimulate AML clonogenic cells in seven patients in direct comparison with the effects of human granulocyte CSF (hG-CSF), human granulocyte...

Acute myeloid leukemia (AML) is the most common type of acute in adults. The incidence AML increases with age. According to Surveillance, Epidemiology, and End Results Program, over 57% new cases occur adults aged 65 years or above (65–74 years: 23.7%; 75–84 22.8%; >84 10.6%).

To the Editor: Sweet syndrome (SS) is a neutrophilic dermatosis with cutaneous papules or plaques and fever arthralgia.1Su W.P. Liu H.N. Diagnostic criteria for Sweet's syndrome.Cutis. 1986; 37: 167-174PubMed Google Scholar SS categorized into classical SS, malignancy-associated (MASS), drug-induced (DI-SS).2Nelson C.A. Noe M.H. McMahon C.M. et al.Sweet in patients without malignancy: retrospec...

Recurrent genomic abnormalities identified in acute myeloid leukemia (AML) improve prognostic stratification of patients with normal karyotype AML AML (NK-AML).1, 2 Retrospective studies show that mutations in FLT3, NPM1, and CEBPα are powerful tools to predict outcomes in younger and older patients with NK-AML.3-5 Limited data exists on the role of allogeneic hematopoietic cell transplant (HCT...