BACKGROUND Radiocontrast nephropathy (RCN) is one of the leading causes of hospital-acquired acute renal insufficiency. Adenosine, a renal vasoconstrictor, is thought to play a role in RCN. In this study, aminophylline, a non-selective adenosine-competitive inhibitor, was evaluated as a potential agent to protect against RCN. METHODS Twenty-six patients treated with 200 mg intravenous aminoph...

The effects of aminophylline given intravenously on the pulmonary circulation and left ventricular performance were studied during combined right and transseptal left heart catheterization in 32 patients with mitral and aortic valvular disease. We recorded complete data on the changes of the pulmonary vascular distending pressure (PD) and the pulmonary blood volume (PBV) before and during amino...

Cheyne-Stokes respiration, found associated with cardiac failure, has been attributed to cerebral anoxia (1) on the basis of decreased cerebral blood flow, which is depressed in proportion to the decrease in cardiac output (2). Since Aminophylline increases cardiac output (3) and at the same time arrests Cheyne-Stokes respiration (4), it seems logical to conclude that the latter response occurs...

1. A wide range of purine bases, nucleosides and cyclic nucleotides were shown to induce betacyanin synthesis in Amaranthus seedlings. 2. The induction of pigment by benzyladenine, dibutyryl cyclic AMP or cyclic AMP was not potentiated by aminophylline. Aminophylline was shown to inhibit Amaranthus cyclic AMP phosphodiesterase activity. 4. Incubation of seedlings with aminophylline inhibited th...

Slow-release aminophylline, although widely used for the prophylaxis of childhood asthma, has had only limited formal assessment. A four-month double-blind cross-over trial of slow-release aminophylline (14 mg/kg twice daily) was carried out in 24 children with perennial asthma. Satisfactory serum theophylline concentrations were obtained in 17 children, with few side effects. There was a signi...

Background: Post-dural puncture headache (PDPH) is commonly seen after neuraxial block and it usually lasts for up to two days or in some cases for up to two weeks. Several types of regimens have been suggested for treatment, such as theophylline and caffeine. This study aimed to evaluate the effects of aminophylline, paracetamol, and administration of aminophylline and paracetamol concurrently...

We tested the hypothesis that adenosine contributes to augmented skeletal muscle vasodilation during hypoxic exercise. In separate protocols, subjects performed incremental rhythmic forearm exercise (10% and 20% of maximum) during normoxia and normocapnic hypoxia (80% arterial O2 saturation). In protocol 1 (n = 8), subjects received an intra-arterial administration of saline (control) and amino...

Iliff BW, Swoap SJ. Central adenosine receptor signaling is necessary for daily torpor in mice. Am J Physiol Regul Integr Comp Physiol 303: R477–R484, 2012. First published July 11, 2012; doi:10.1152/ajpregu.00081.2012.—When calorically restricted at cool ambient temperatures, mice conserve energy by entering torpor, during which metabolic rate (MR), body temperature (Tb), heart rate (HR), and ...