Brown adipocytes mainly utilize glucose and fatty acids to produce energy, which play key roles in thermogenesis. Furthermore, brown also other substrates, such as amino acids, for energy expenditure various conditions. Here, we report the new physiological of proton-coupled acid transporters, SLC36A2 SLC36A3, on global metabolism. The relative mRNA expression levels both Slc36a2 Slc36a3 were a...

Coprinus comatus polysaccharide (CCP) has significant hepatoprotective effect. To explore mechanism of CCP, the study analyzed preventive effect CCP on acute alcoholic liver injury in mice by histopathological examination and biochemical analysis. Simultaneously, was also conjunction with metabolomics proliferation gut microbiota. The results showed that significantly decreased alanine a...

Leucine-responsive regulatory protein (Lrp) is a transcriptional regulator for the genes involved in transport, biosynthesis and catabolism of amino acids in Escherichia coli. In order to identify the whole set of genes under the direct control of Lrp, we performed Genomic SELEX screening and identified a total of 314 Lrp-binding sites on the E. coli genome. As a result, the regulation target o...

The architecture of plant metabolism includes substantial duplication of metabolite pools and enzyme catalyzed reactions in different subcellular compartments. This poses challenges for understanding the regulation of metabolism particularly in primary metabolism and amino acid biosynthesis. To explore the extent to which amino acids are made in single compartments and to gain insight into the ...

description of naturally occurring amino acids and peptides (Chapter I); among the former group more than 170 compounds have now been obtained from plant, animal, and microbial sources; in the latter group, the types of compound range from the simple dipeptides carnosine and anserine to the structurally complex antibiotics and peptide hormones. The role of amino acids in the nutrition of both h...