A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and tert-butyltetrazole moieties differ in chain length, basicity substitution. Compounds were tested for their antiplasmodial activity against Plasmodium falciparum NF54 as well cytotoxicity L-6-cells. The strongly influenced by link...

Objective: Docking studies and synthesis of 4-aryl-5H-chromeno [4,3 -d]pyrimidine-2-amine derivatives to evaluate antimicrobial and in vitro cytotoxicity activity. Methods: Docking studies were performed on Autodock Vina. Computational work was carried out with UCSF Chimera, Argus lab, Marvin beans. Antimicrobial activity was carried out with the agar cup plate method on two gram-positive organ...

New 5-[1-(anthracen-9(10H)-ylideneamino)-2-(1H-imidazol-5-yl)ethyl]-1,3,4-thiadiazol-2-amine 3 has been synthesized from condensation reaction of N-anthracen-9(10H)-ylidenehistidine 2 with thiosemicarbazide in phosphorusoxy chloride. The prepared compounds were characterized by FTIR spectroscopy, electronic spectroscopy, NMR and NMR. Preliminary in vitro tests for fungicidal activity show that ...

Addition of ammonium acetate fo llowed by commerc ial zinc dust to the solution of azo compounds in methanol appcars to o ffer a general and convenient mea ns for reducing bot h sym metri ca l and unsymmetrical azo compounds to the corresponding amine/s at ambient temperature. Many other reducible and hydrogenolysable groups like -OCH1. -OH. -COOH, -CH1• -COCH) and halogens are to lerated. The ...

a mild and efficient one-pot three-component and environmentally benign approach for the synthesis of a wide range of hydantoin annulated derivatives has been described. a multi-component reaction between a carbonyl compounds (ketone or aldehyde), potassium cyanide and ammonium carbonate (as cyanating agent and amine source, respectively leads to the formation of hydantoins. the proposed optimi...

Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophyt...

Using aroyl hydrazides as a source of amine and substituted aromatic aldehydes as a carbonyl source, we have synthesized aroyl hydrazide derivatives by condensation reaction. The synthesized compounds were characterized by FT-IR, 1H-NMR and 13C-NMR spectral studies. The Synthesized compounds were subjected to antimicrobial and anti-oxidant activities. Finally, molecular docking study had been p...

Almost all drug compounds will elicit deleterious effects on cells at some concentration. Lysosome perturbation as a result of ion trapping of amine containing compounds has been demonstrated to cause the formation of autophagosomes and autophagic cytopathology. Here we describe the use of the EL406TM Combination Washer Dispenser to automatically aspirate media, wash cells and dispense reagents...

microcantilevers (mcls) are cost-effective and highly sensitive devices for biodetection. adsorption of specific analytes on the microcantilever surface causes the bending of mcl through changing of the surface characteristics. these new bioprobes designed in a way that one side of the microcantilever surface is coated with a selective receptor that absorbs particular molecules. after surface a...